cholesterol monooxygenase (side-chain-cleaving) activity
Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
Related Synonyms
C27-side chain cleavage enzyme
cholesterol 20-22-desmolase activity
cholesterol C(20-22) desmolase activity
cholesterol C20-22 desmolase activity
cholesterol desmolase activity
cholesterol side-chain cleavage enzyme activity
cholesterol side-chain-cleaving enzyme activity
cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
cytochrome P-450scc
cytochrome p450scc
desmolase, steroid 20-22
enzymes, cholesterol side-chain-cleaving
Narrow Synonyms
Cyp11a1
cytochrome P-450(scc) activity
cytochrome p450(scc) activity
Broad Synonyms
steroid 20-22 desmolase activity
steroid 20-22-lyase activity
class Information
has_dbxref
- EC:1.14.15.6
- MetaCyc:1.14.15.6-RXN
- Reactome:R-HSA-193065
- Reactome:R-HSA-193054
- Reactome:R-HSA-193101
- RHEA:35739
has_obo_namespace
molecular_function
class Relations
Subclass of
- steroid hydroxylase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
- has participantrosomewaterchebi
- has participantrosomehydronchebi
- has participantrosomedioxygenchebi
- has participantrosomecholesterolchebi
- has participantrosomepregnenolonechebi
- has participantrosome4-methylpentanalchebi
- has participantrosomedi-mu-sulfido-diiron(2+)chebi
- has participantrosomedi-mu-sulfido-diiron(1+)chebi