lipoate-protein ligase activity
Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP.
Narrow Synonyms
lipoate-protein ligase A activity
lipoate-protein ligase activity (lipoylation of glycine cleavage complex)
lipoate-protein ligase B activity
class Information
has_alternative_id
has_dbxref
- EC:6.3.1.20
- MetaCyc:RXN0-1141
- MetaCyc:RXN0-5098
- MetaCyc:RXN-17127
- RHEA:49288
has_obo_namespace
molecular_function
term tracker item
class Relations
Subclass of
- nucleotidyltransferase activity
- ligase activity, forming carbon-nitrogen bonds
- catalytic activity, acting on a protein
- has participantrosomehydronchebi
- has participantrosomeL-lysinium residuechebi
- has participantrosomeATP(4-)chebi
- has participantrosomediphosphate(3-)chebi
- has participantrosomeadenosine 5'-monophosphate(2-)chebi
- has participantrosome(R)-lipoatechebi
- has participantrosomeN(6)-[(R)-lipoyl]-L-lysine residuechebi