lovastatin nonaketide synthase activity
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.
Related Synonyms
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
class Information
has_dbxref
- EC:2.3.1.161
- KEGG_REACTION:R07251
- MetaCyc:2.3.1.161-RXN
- RHEA:18565
has_obo_namespace
molecular_function
class Relations
Subclass of
- acyltransferase activity, transferring groups other than amino-acyl groups
- has participantrosomewaterchebi
- has participantrosomehydronchebi
- has participantrosomecarbon dioxidechebi
- has participantrosomecoenzyme A(4-)chebi
- has participantrosomemalonyl-CoA(5-)chebi
- has participantrosomeNADPH(4-)chebi
- has participantrosomeS-adenosyl-L-homocysteine zwitterionchebi
- has participantrosomeNADP(3-)chebi
- has participantrosomeS-adenosyl-L-methionine zwitterionchebi
- has participantrosomeO-(pantetheine-4'-phosphoryl)serine(1-) residuechebi
- has participantrosomeO-[S-(dihydromonacolin L carboxy)pantetheine-4'-phosphoryl]-L-serine(1-) residuechebi