OntologiesgoclassesGO:0097452   
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GAIT complex
http://purl.obolibrary.org/obo/GO_0097452

A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.

Also appears ingexoprccoretorexo
Exact Synonyms
gamma interferon-activated inhibitor of translation complex
IFN-gamma-activated inhibitor of translation complex
class Information
created_by

pr

creation_date

2012-12-19T09:32:25Z

has_obo_namespace

cellular_component

class Relations