A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
class Information
class Relations
- glial cellcl
- central nervous system macrophagecl
- obsolete protein-containing material entitypr
- has plasma membrane partrosomeintegrin alpha-Mpr
- has plasma membrane partrosomeadhesion G protein-coupled receptor E1pr
- has plasma membrane partrosomemacrosialinpr
- develops fromrosomemesodermal cellcl
- develops fromrosome(stem cellclandpart ofrosomeyolk sacuberon)
- capable ofrosomeinnate immune responsego