An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04)
class Information
A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.
65646-68-6
C26H33NO2
C1098
- CTRP
- FDA
- GDC
Fenretinide
187EJ7QEXL
Fenretinide
Fenretinide
39582
374551
39582
39582
Fenretinide
- Organic Chemical
- Pharmacologic Substance
C0060197
class Relations
- Retinoic Acid Agent
- Chemical_Or_Drug_Has_Mechanism_Of_ActionsomeRetinoic Acid Receptor Activation
- Chemical_Or_Drug_Has_Physiologic_EffectsomeApoptosis
- Chemical_Or_Drug_Has_Physiologic_EffectsomeNegative Regulation of Angiogenesis
- Chemical_Or_Drug_Has_Physiologic_EffectsomePositive Regulation of Cell Differentiation
- Chemical_Or_Drug_Affects_Gene_ProductsomeRetinoic Acid Receptor