OntologiesncitclassesNCIT:C1098   
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Fenretinide
http://purl.obolibrary.org/obo/NCIT_C1098

An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04)

Exact Synonyms
4-(all-trans-retino-yl)aminophenol
4-HPR
4-Hydroxyphenylretinamide
all-trans-4'-hydroxyretinanilide
All-trans-4'-Hydroxyretinanilide
all-trans-N-(4-Hydroxyphenyl)retinamide
all-trans-N-4'-hydroxyretinanilide
fenretinide
FENRETINIDE
Fenretinide
Fenretinimide
HPR-4
McN-R-1967
N-(4-hydroxyphenyl)retinamide
class Information
ALT_DEFINITION

A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.

CAS_Registry

65646-68-6

Chemical_Formula

C26H33NO2

code

C1098

Contributing_Source
  • CTRP
  • FDA
  • GDC
Display_Name

Fenretinide

FDA_UNII_Code

187EJ7QEXL

Is_Value_For_GDC_Property

Pharmacologic Substance

Legacy Concept Name

Fenretinide

Maps_To

Fenretinide

NCI_Drug_Dictionary_ID

39582

NSC Number

374551

PDQ_Closed_Trial_Search_ID

39582

PDQ_Open_Trial_Search_ID

39582

Preferred_Name

Fenretinide

Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
UMLS_CUI

C0060197

class Relations