OntologiesncitclassesNCIT:C111037   
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Synthetic Long E6/E7 Peptides Vaccine HPV-01
http://purl.obolibrary.org/obo/NCIT_C111037

A therapeutic peptide vaccine consisting of thirteen synthetic long peptides (SLPs), which are 25-35 amino acids in size, derived from the human papillomavirus (HPV) type 16 oncoproteins E6 and E7, with potential immunostimulating and antitumor activities. Upon administration, synthetic long E6/E7 peptides vaccine HPV-01 is taken up and degraded into small pieces by dendritic cells. The processed viral epitopes are presented by dendritic cells, which may stimulate the host immune system to mount both cytotoxic T-cell lymphocyte (CTL) and helper T cell responses against HPV E6/E7-expressing tumor cells. This results in the destruction of tumor cells and leads to decreased tumor growth. The E6 and E7 oncoproteins are implicated in the tumorigenesis in a variety of cancers. The SLPs allow for optimal presentation by antigen-presenting cells.

Exact Synonyms
HPV-01
ISA101
SLP-HPV-01
Synthetic Long E6/E7 Peptides Vaccine HPV-01
class Information
code

C111037

Contributing_Source
  • CTRP
  • GDC
Display_Name

Synthetic Long E6/E7 Peptides Vaccine HPV-01

Is_Value_For_GDC_Property

Pharmacologic Substance

Maps_To

Synthetic Long E6/E7 Peptides Vaccine HPV-01

NCI_Drug_Dictionary_ID

751803

NCI_META_CUI

CL453544

PDQ_Closed_Trial_Search_ID

751803

PDQ_Open_Trial_Search_ID

751803

Preferred_Name

Synthetic Long E6/E7 Peptides Vaccine HPV-01

Semantic_Type
  • Immunologic Factor
  • Pharmacologic Substance
class Relations