OntologiesncitclassesNCIT:C117235   
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IDH1R132H-Specific Peptide Vaccine PEPIDH1M
http://purl.obolibrary.org/obo/NCIT_C117235

A peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1 (IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic activity. Intradermal vaccination with the IDH1R132H-specific peptide vaccine PEPIDH1M may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the IDH1R132H protein. The IDH1 point mutation of amino acid residue 132 is highly expressed in gliomas and is associated with increased production of the oncometabolite R-2-hydroxyglutarate (2HG).

Exact Synonyms
IDH1R132H-Specific Peptide Vaccine PEPIDH1M
PEPIDH1M Vaccine
PEPIDH1M
class Information
code

C117235

Contributing_Source
  • CTRP
  • GDC
Display_Name

IDH1R132H-Specific Peptide Vaccine PEPIDH1M

Is_Value_For_GDC_Property

Pharmacologic Substance

Maps_To

IDH1R132H-Specific Peptide Vaccine PEPIDH1M

NCI_Drug_Dictionary_ID

763159

NCI_META_CUI

CL474105

PDQ_Closed_Trial_Search_ID

763159

PDQ_Open_Trial_Search_ID

763159

Preferred_Name

IDH1R132H-Specific Peptide Vaccine PEPIDH1M

Semantic_Type
  • Immunologic Factor
  • Pharmacologic Substance
class Relations