IDH1R132H-Specific Peptide Vaccine PEPIDH1M
A peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1 (IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic activity. Intradermal vaccination with the IDH1R132H-specific peptide vaccine PEPIDH1M may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the IDH1R132H protein. The IDH1 point mutation of amino acid residue 132 is highly expressed in gliomas and is associated with increased production of the oncometabolite R-2-hydroxyglutarate (2HG).
Exact Synonyms
IDH1R132H-Specific Peptide Vaccine PEPIDH1M
PEPIDH1M Vaccine
PEPIDH1M
class Information
code
C117235
Contributing_Source
- CTRP
- GDC
Display_Name
IDH1R132H-Specific Peptide Vaccine PEPIDH1M
Has_Target
in_subset
Is_Value_For_GDC_Property
Maps_To
IDH1R132H-Specific Peptide Vaccine PEPIDH1M
NCI_Drug_Dictionary_ID
763159
NCI_META_CUI
CL474105
PDQ_Closed_Trial_Search_ID
763159
PDQ_Open_Trial_Search_ID
763159
Preferred_Name
IDH1R132H-Specific Peptide Vaccine PEPIDH1M
Semantic_Type
- Immunologic Factor
- Pharmacologic Substance