OntologiesncitclassesNCIT:C119616   
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hTERT Multipeptide/Montanide ISA-51 VG/Imiquimod Vaccine GX 301
http://purl.obolibrary.org/obo/NCIT_C119616

A therapeutic cancer vaccine consisting of four epitopes derived from the human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, including hTERT (540-548) acetate, hTERT (611-626) acetate, hTERT (672-686) acetate and hTERT (766-780) acetate, emulsified individually in the adjuvant montanide ISA-51 VG and administered with the immune response modifier (IRM) imiquimod, with potential immunostimulating and antineoplastic activities. Each hTERT peptide emulsion is administered individually by intradermal injection. Subsequently, imiquimod is applied topically to the injection site(s). Vaccination with GX 301 may elicit a cytotoxic T-cell (CTL) response against telomerase-expressing tumor cells. Telomerase is expressed in the majority of human cancer cells, infrequently expressed in normal cells, and is directly linked to tumorigenesis. Imiquimod stimulates cytokine production through the activation of toll-like receptor 7 (TLR-7), and also exhibits antiproliferative effects. Montanide ISA-51, also known as incomplete Freund's adjuvant (IFA), is a stabilized water-in-oil emulsion containing mineral oil with mannide oleate, which contains vegetable-grade (VG) oleic acid derived from olive oil. ISA-51 non-specifically stimulates cell-mediated immune responses to antigens.

Exact Synonyms
GX 301
GX301
hTERT Multipeptide/Montanide ISA-51 VG/Imiquimod Vaccine GX 301
class Information
code

C119616

Contributing_Source

GDC

Is_Value_For_GDC_Property

Pharmacologic Substance

Maps_To

hTERT Multipeptide/Montanide ISA-51 VG/Imiquimod Vaccine GX 301

NCI_Drug_Dictionary_ID

766744

PDQ_Closed_Trial_Search_ID

766744

PDQ_Open_Trial_Search_ID

766744

Preferred_Name

hTERT Multipeptide/Montanide ISA-51 VG/Imiquimod Vaccine GX 301

Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
UMLS_CUI

C3896843

class Relations