PH Domain
Pleckstrin-homology (PH) domains are protein modules of approximately 120 amino acids found in a wide variety of signaling proteins in organisms ranging from yeast to humans. Some PH domains bind with high affinity (low mM or nM Kd) to specific phosphoinositides such as phosphatidyl-inositol (PI) -4,5-bisphosphate, PI-3,4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/lambda subunits of heterotrimeric G proteins.
Exact Synonyms
PH Domain
Pleckstrin Homology Domain
Pleckstrin-Homology Domain
class Information
code
C14077
Legacy Concept Name
PH_Domain
Preferred_Name
PH Domain
Semantic_Type
Amino Acid Sequence
UMLS_CUI
C1518792
class Relations
Subclass of
Related from
Gene_Product_Has_Structural_Domain_Or_Motif
- Ras GTPase-Activating Protein nGAP
- Oxysterol-Binding Protein-Related Protein 10
- SH2B Adapter Protein 1
- Pleckstrin Homology-Like Domain Family A Member 2
- Lipopolysaccharide-Responsive and Beige-Like Anchor Protein
- Pleckstrin Homology-Like Domain Family B Member 3
- Oxysterol-Binding Protein 2
- Oncogene TIM Protein
- Serine/Threonine-Protein Kinase D2
- Pleckstrin Homology Domain-Containing Family G Member 5