OntologiesncitclassesNCIT:C173955   
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Anti-CD20 Monoclonal Antibody BAT4306F
http://purl.obolibrary.org/obo/NCIT_C173955

A recombinant, glycosylation-modified monoclonal antibody directed against the human B-cell-specific cell surface antigen CD20, with potential antineoplastic and immunomodulating activities. Upon administration of anti-CD20 monoclonal antibody BAT4306F, the antibody specifically targets and binds to CD20. This induces antibody-dependent cell-mediated cytotoxicity (ADCC) against CD20-expressing B-cells, which leads to B-cell apoptosis and the inhibition of tumor cell proliferation. CD20, a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B-cells during most stages of B-cell development, is often overexpressed in B-cell malignancies. The complete defucosylation of BAT4306F may result in enhanced ADCC.

Exact Synonyms
Anti-CD20 Monoclonal Antibody BAT4306F
BAT 4306F
BAT-4306F
BAT4306F
class Information
code

C173955

Contributing_Source

GDC

Is_Value_For_GDC_Property

Pharmacologic Substance

Maps_To

Anti-CD20 Monoclonal Antibody BAT4306F

NCI_Drug_Dictionary_ID

802165

NCI_META_CUI

CL1407872

PDQ_Closed_Trial_Search_ID

802165

PDQ_Open_Trial_Search_ID

802165

Preferred_Name

Anti-CD20 Monoclonal Antibody BAT4306F

Semantic_Type

Pharmacologic Substance

class Relations