OntologiesncitclassesNCIT:C17532   
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Retinoic Acid Receptor
http://purl.obolibrary.org/obo/NCIT_C17532

Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity.

Exact Synonyms
NR1B
Nuclear Receptor Subfamily 1 Group B
RAR
Retinoic Acid Receptor
Retinoid Receptor
class Information
code

C17532

Contributing_Source

CTRP

DesignNote

A protein that binds retinoic acid with high affinity. Binding of ligand to RARs attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. (from OMIM 180240 and NCI)

Display_Name

Retinoic Acid Receptor

Legacy Concept Name

Retinoic_Acid_Receptor

Preferred_Name

Retinoic Acid Receptor

Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
UMLS_CUI

C0140278

class Relations