Apoptosis
A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell.
Exact Synonyms
APOPTOSIS
Apoptosis
apoptosis
Apoptotic Process
PCD
Programmed Cell Death
programmed cell death
class Information
ALT_DEFINITION
- A form of programmed cell death triggered by internal or external signals that results in a series of characteristic morphological changes.
- A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.
code
C17557
Contributing_Source
CDISC
DesignNote
Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.
in_subset
Legacy Concept Name
Apoptosis
Preferred_Name
Apoptosis
Semantic_Type
Phenomenon or Process
UMLS_CUI
C0162638
class Relations
Subclass of
Related from
Gene_Plays_Role_In_Process
- KHDRBS1 Gene
- ITGAM Gene
- TNFRSF25 Gene
- RIPK3 Gene
- TNFRSF11B Gene
- UBE4B Gene
- ACVR1C Gene
- LGALS7 Gene
- STAT5B Gene
- PERP Gene
- NAE1 Gene
- TNFSF10 Gene
- MAP3K7 Gene
- IL3 Gene
- TNF Receptor Family Gene
- PIK3R2 Gene
- SNCA Gene
- PTMA Gene
- TNFRSF10A Gene
- CD27 Gene
- NOTCH1 Gene
- PNMA1 Gene
- CASP3 Gene
- FAS Gene
- PNMA2 Gene
- CASP1 Gene
- TFDP1 Gene
- BRAF Gene
- TFAP4 Gene
- APP Gene
- PGAP2 Gene
- Apoptosis Regulation Gene
- KLLN Gene
- DCC Gene
- PAX3 Gene
- CASP8 Gene
- PDCD1 Gene
- RIPK2 Gene
- PAK6 Gene
- PSMB5 Gene
- TAF6 Gene
- NFKB1 Gene
- PTK2B Gene
- ATM Gene
- CASP2 Gene
- MAP2K6 Gene
- E2F1 Gene
- NFKBIA Gene
- TPD52L1 Gene
- ZNF385B Gene
- MAGED1 Gene
- TNFSF11 Gene
- TFDP2 Gene
- IL1B Gene
- PPP2R1A Gene
- CIB1 Gene
- GAS2 Gene
- FOXL2 Gene
- PHLDA2 Gene
- PRKCE Gene
- STK3 Gene
- MELK Gene
- TP53BP2 Gene
- LGALS7B Gene
- BCL6 Gene
- PPP1R13L Gene
- TNFRSF12A Gene
- TNFSF9 Gene
- CCN1 Gene
- PTK2 Gene
- FOXO3 Gene
- MAPK9 Gene
- C19orf12 Gene
- GADD45A Gene
- RELT Gene
- YWHAZ Gene
- CAV2 Gene
- SQSTM1 Gene
- CD14 Gene
- GADD45B Gene
- FASTK Gene
- CASP6 Gene
- SCRIB Gene
- PMAIP1 Gene
- ABL1 Gene
- MAPK14 Gene
- NOD2 Gene
- CASP7 Gene
- RIPK1 Gene
- PREX1 Gene
- TGM2 Gene
- DAXX Gene
- CALR Gene
- CASP9 Gene
- YARS1 Gene
- TRAF1 Gene
- BECN2 Gene
- PSMD10 Gene
- SIAH2 Gene
- EIF5A Gene
- FADD Gene
- ANGPT1 Gene
- PAK1 Gene
- RAD21 Gene
- WWOX Gene
- RAC1 Gene
- BUB1B Gene
- AGTR2 Gene
- PSME3 Gene
- TNFRSF18 Gene
- Caspase Gene
- STK4 Gene
- KRT20 Gene
- DEPTOR Gene
- DOCK1 Gene
- HUWE1 Gene
- IAPP Gene
- NRP1 Gene
- BEX3 Gene
- CARD8 Gene
- PTPN6 Gene
- IFNA2 Gene
- DUSP22 Gene
- ACHE Gene
- TRAF2 Gene
- CDK11B Gene
- IRF1 Gene
- ING1 Gene
- PSEN2 Gene
- MX1 Gene
- CASP5 Gene
- TNFRSF1B Gene
- TNFAIP3 Gene
- PSENEN Gene
- DNM1L Gene
- PRF1 Gene
- UBA3 Gene
- SATB2 Gene
- BCL-2 Gene Family
- VDAC1 Gene
- TNFSF12 Gene
- FASLG Gene
- BBC3 Gene
- TNFRSF21 Gene
- TNFRSF19 Gene
- CCR8 Gene
- CASP10 Gene
- GDNF Gene
- SFRP1 Gene
- CXCR4 Gene
- TNF Gene
- MAPK8 Gene
- STK11 Gene
- PDCD4 Gene
- CASP4 Gene
- LGALS8 Gene
- TNFSF14 Gene
- CDK11A Gene
- TP53AIP1 Gene
- BECN1 Gene
- NBN Gene
- AATF Gene
- TNFRSF1A Gene
- ADRA1A Gene
Gene_Product_Plays_Role_In_Biological_Process
- Paraneoplastic Antigen Ma2
- Apoptosis Regulator
- WW Domain-Containing Oxidoreductase
- Pleckstrin Homology-Like Domain Family A Member 2
- Killin
- Tumor Protein D53
- Protein JTB
- Cleft Lip and Palate Transmembrane Protein 1-Like Protein
- BCL-2 Family Protein
- Caspase
- Eukaryotic Translation Initiation Factor 5A-1
- Transcription Factor AP-4
- E3 Ubiquitin-Protein Ligase SIAH2
- Nuclear Factor NF-kappa-B p50 Subunit
Chemical_Or_Drug_Has_Physiologic_Effect
- LMB-7 Immunotoxin
- Irinotecan
- DACH Polymer Platinate AP5346
- LMB-1 Immunotoxin
- Fenretinide Phospholipid Suspension ST-001
- Liposomal Oxaliplatin
- Belotecan Hydrochloride
- Pegylated Liposomal Irinotecan
- Shark Cartilage Extract AE-941
- Alitretinoin
- Oxaliplatin
- Cabazitaxel
- Fenretinide
- Oral Irinotecan Hydrochloride Formulation VAL-413
- Fenretinide Lipid Matrix
- Gimatecan
- LMB-9 Immunotoxin
- Irinotecan Hydrochloride
Biological_Process_Has_Result_Biological_Process