OntologiesncitclassesNCIT:C17557   
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Apoptosis
http://purl.obolibrary.org/obo/NCIT_C17557

A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell.

Exact Synonyms
APOPTOSIS
Apoptosis
apoptosis
Apoptotic Process
PCD
Programmed Cell Death
programmed cell death
class Information
ALT_DEFINITION
  • A form of programmed cell death triggered by internal or external signals that results in a series of characteristic morphological changes.
  • A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.
code

C17557

Contributing_Source

CDISC

DesignNote

Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.

Legacy Concept Name

Apoptosis

Preferred_Name

Apoptosis

Semantic_Type

Phenomenon or Process

UMLS_CUI

C0162638

class Relations
Related from
Gene_Plays_Role_In_Process
Biological_Process_Has_Result_Biological_Process