OntologiesncitclassesNCIT:C18060   
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Somatic Variation
http://purl.obolibrary.org/obo/NCIT_C18060

Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though they will be transmitted during any mitosis within the individual. Somatic mutations may contribute to a broad variety of pathologies including cancer.

Exact Synonyms
Somatic Mutation Abnormality
somatic mutation
Somatic Mutation
Somatic Variant
Somatic Variation
SOMATIC VARIATION
class Information
ALT_DEFINITION
  • An alteration in DNA that occurs after conception. Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children. These alterations can (but do not always) cause cancer or other diseases.
  • Any non-inheritable variation in the DNA that is not transmitted to the progeny but will be maintained during any mitosis within the individual.
code

C18060

Contributing_Source
  • CDISC
  • CTRP
  • GDC
Display_Name

Somatic Mutation

Is_Value_For_GDC_Property

Genetic Variant Origin Indicator

Legacy Concept Name

Somatic_Mutation

Maps_To

Somatic

Preferred_Name

Somatic Variation

Semantic_Type

Cell or Molecular Dysfunction

UMLS_CUI

C0544886

class Relations