Soluble Guanylate Cyclase
Human Soluble Guanylate Cyclases (Adenylyl Cyclase 4/Guanylyl Cyclase Family) are heterodimeric (alpha/beta) nitric oxide-activated cytoplasmic enzymes that catalyze conversion of GTP to cGMP second messenger. The main receptors for nitric oxide in the cardiovascular system and for nitrovasodilator drugs, alpha/beta interaction is required for guanylyl cyclase activity. (NCI)
Exact Synonyms
EC 4.6.1.2
Guanylate Cyclase, Soluble
GUCY
sGC
Soluble Guanylate Cyclase
Soluble Guanylyl Cyclase
class Information
code
C20141
DesignNote
Protein_Plays_Role_In_Biological_Process: cGMP Synthesis
Legacy Concept Name
Soluble_Guanylate_Cyclase
Preferred_Name
Soluble Guanylate Cyclase
Semantic_Type
- Amino Acid, Peptide, or Protein
- Enzyme
UMLS_CUI
C1097411