OntologiesncitclassesNCIT:C20514   
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Interleukin-12
http://purl.obolibrary.org/obo/NCIT_C20514

Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)

Exact Synonyms
CLMF
Cytotoxic Lymphocyte Maturation Factor
IL-12 p70
IL-12p70
IL-12
IL12
Interleukin 12
Interleukin-12
Natural Killer Cell Stimulatory Factor
NKSF