Interleukin-12
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
Exact Synonyms
CLMF
Cytotoxic Lymphocyte Maturation Factor
IL-12 p70
IL-12p70
IL-12
IL12
Interleukin 12
Interleukin-12
Natural Killer Cell Stimulatory Factor
NKSF
class Information
code
C20514
Contributing_Source
CTRP
Display_Name
Interleukin-12
Legacy Concept Name
Interleukin-12
Preferred_Name
Interleukin-12
Semantic_Type
- Amino Acid, Peptide, or Protein
- Immunologic Factor
UMLS_CUI
C0123759
class Relations
Subclass of
- Protein or Riboprotein Complex
- Gene_Product_Has_Organism_SourcesomeHuman
- Gene_Product_Has_Biochemical_FunctionsomeInterleukin
- Gene_Product_Plays_Role_In_Biological_ProcesssomeIntercellular Communication Process
- Gene_Product_Plays_Role_In_Biological_ProcesssomeCell Differentiation Process
- Gene_Product_Plays_Role_In_Biological_ProcesssomeCell-Mediated Immunity
- Gene_Product_Plays_Role_In_Biological_ProcesssomeT-Cell Activation
- Gene_Product_Plays_Role_In_Biological_ProcesssomeNK Cell Activation