gp100-Pulsed Peripheral Blood Mononuclear Cell
Peripheral blood lymphocytes (PBL) harvested from host blood and stimulated in vitro with tumor-specific gp 100 antigen. 'Pulsing' PBL with gp100, a tumor associated antigen (TAA) commonly expressed by melanoma cells, may increase melanoma-reactive cytotoxic lymphocytes (CTL) in the PBL cell population. Autologous gp100-pulsed PBL have been administered to melanoma patients in order to augment cytotoxic immune responses to melanoma. (NCI04)
Exact Synonyms
gp100-Pulsed PBL
gp100-pulsed Peripheral Blood Lymphocyte
gp100-Pulsed Peripheral Blood Mononuclear Cell
class Information
code
C2762
Has_Target
Legacy Concept Name
gp100-pulsed_PBL
NSC Number
672644
Preferred_Name
gp100-Pulsed Peripheral Blood Mononuclear Cell
Semantic_Type
- Cell
- Pharmacologic Substance
UMLS_CUI
C1515628
class Relations
Subclass of
- Peripheral Blood Lymphocyte Vaccine
- Chemical_Or_Drug_Has_Mechanism_Of_ActionsomeAntigen Sensitization
- Chemical_Or_Drug_Has_Physiologic_EffectsomeT-Cell Activation
- Chemical_Or_Drug_Has_Physiologic_EffectsomeImmunopotentiation
- Chemical_Or_Drug_Affects_Abnormal_CellsomeMelanoma Cell
- Chemical_Or_Drug_Affects_Cell_Type_Or_TissuesomeCytotoxic T-Lymphocyte