A rare neoplasm arising from the ovary. Although it may occur at any age, it is more often seen in young females. Morphologically, it is characterized by a mixture of two cellular populations: well differentiated Sertoli cells and granulosa cells, with the latter constituting at least ten percent of the neoplasm. The vast majority of cases are stage I lesions at presentation and produce either estrogenic or androgenic manifestations. Although it may present as a massive ovarian tumor, it usually follows a benign clinical course. Very rare case reports of testicular lesions morphologically resembling gynandroblastomas are in fact variants of juvenile granulose cell tumor, or Sertoli cell tumor, or a combination of both.
class Information
C3072
GDC
8632/1
Gynandroblastoma
- 8632/1
- Gynandroblastoma
Undetermined
Ovarian Gynandroblastoma
Neoplastic Process
C0018413
class Relations
- (Ovarian Sex Cord-Stromal TumorandDisease_Has_Abnormal_CellsomeNeoplastic Granulosa CellandDisease_Has_Abnormal_CellsomeNeoplastic Sertoli CellandDisease_Has_FindingsomeMicrofollicular Structures PresentandDisease_Has_FindingsomeTubular Structures PresentandDisease_May_Have_Molecular_AbnormalitysomeSomatic DICER1 RNase IIIb Hotspot Gene Mutation)