OntologiesncitclassesNCIT:C3174   
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Chronic Myeloid Leukemia, BCR-ABL1 Positive
http://purl.obolibrary.org/obo/NCIT_C3174

A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.

Exact Synonyms
BCR-ABL Positive Chronic Myelogenous Leukemia
chronic granulocytic leukemia
Chronic Granulocytic Leukemia
Chronic Myelocytic Leukemia
Chronic Myelogenous Leukemia (CML)
Chronic myelogenous leukemia, BCR-ABL positive
Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Chronic Myelogenous Leukemia, BCR::ABL1 Positive
Chronic Myelogenous Leukemia
chronic myelogenous leukemia
Chronic Myelogenous Leukemias
Chronic Myeloid Leukemia, BCR-ABL1 Positive
Chronic Myeloid Leukemia, BCR::ABL1 Positive
Chronic Myeloid Leukemia
chronic myeloid leukemia
CML - Chronic Myelogenous Leukemia
CML
Hematopoeitic - Chronic Myelocytic Leukemia (CML)
class Information
ALT_DEFINITION

A slowly progressing disease in which too many white blood cells are made in the bone marrow.

code

C3174

Contributing_Source
  • Cellosaurus
  • CPTAC
  • CTRP
  • GDC
Display_Name

Chronic Myelogenous Leukemia, BCR-ABL1 Positive

ICD-O-3_Code
  • 9863/3
  • 9875/3
Legacy Concept Name

Chronic_Myelogenous_Leukemia

Maps_To
  • 9863/3
  • 9875/3
  • Chronic granulocytic leukemia, NOS
  • Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
  • Chronic myeloid leukemia, NOS
  • Chronic myelocytic leukemia, NOS
  • Chronic myeloid leukemia without mention of having achieved remission
  • Chronic myeloid leukaemia [CML], BCR/ABL-positive
  • Chronic myelogenous leukemia, BCR/ABL positive
  • Chronic myelogenous leukemia, BCR-ABL positive
  • Myeloid leukemia, chronic
Neoplastic_Status

Malignant

Preferred_Name

Chronic Myeloid Leukemia, BCR-ABL1 Positive

Semantic_Type

Neoplastic Process

UMLS_CUI

C0023473

class Relations