A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.
class Information
A slowly progressing disease in which too many white blood cells are made in the bone marrow.
C3174
- Cellosaurus
- CPTAC
- CTRP
- GDC
Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- 9863/3
- 9875/3
- GDC Terminology
- Mapped ICDO3.1 Terminology
- Mapped ICDO3.1 Morphology Terminology
- Cellosaurus Terminology
- Mapped ICDO3.1 Morphology PT Terminology
- CTRP Terminology
- CPTAC Neoplasms Codelist
- Clinical Trials Search-Application Programming Interface Disease Category Terminology
- CTS-API Disease Main Type Terminology
- Mapped ICDO3.2 Morphology PT Terminology
- Mapped ICDO3.2 Morphology Terminology
- Mapped ICDO3.2 Terminology
- CPTAC Codelists Terminology
- NCIt Neoplasm Core Terminology
- GDC Value Terminology
- CTRP Disease Terminology
- CPTAC Terminology
- Cellosaurus Disease Terminology
Chronic_Myelogenous_Leukemia
- 9863/3
- 9875/3
- Chronic granulocytic leukemia, NOS
- Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
- Chronic myeloid leukemia, NOS
- Chronic myelocytic leukemia, NOS
- Chronic myeloid leukemia without mention of having achieved remission
- Chronic myeloid leukaemia [CML], BCR/ABL-positive
- Chronic myelogenous leukemia, BCR/ABL positive
- Chronic myelogenous leukemia, BCR-ABL positive
- Myeloid leukemia, chronic
Malignant
Chronic Myeloid Leukemia, BCR-ABL1 Positive
Neoplastic Process
C0023473
class Relations
- (Myeloid LeukemiaandMyeloproliferative NeoplasmandDisease_Has_Normal_Cell_OriginsomePluripotent Bone Marrow Stem CellandDisease_Has_Molecular_AbnormalitysomeBCR-ABL1 Fusion Protein ExpressionandDisease_Has_FindingsomeSplenomegalyandDisease_Has_FindingsomeHypercellular Bone MarrowandDisease_Excludes_Molecular_AbnormalitysomePDGFRA Gene RearrangementandDisease_Excludes_Molecular_AbnormalitysomePDGFRB Gene RearrangementandDisease_Excludes_Molecular_AbnormalitysomeFGFR1 Gene RearrangementandDisease_Mapped_To_GenesomeABL1 GeneandDisease_Mapped_To_GenesomeBCR/ABL1 Fusion Gene)