Protein Kinase B
Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake.
Exact Synonyms
AKT
Akt
protein kinase B
Protein Kinase B
class Information
ALT_DEFINITION
A group of enzymes involved in several processes related to cell growth and survival. Protein kinase B enzymes help to transfer signals inside cells. A protein kinase B enzyme is a type of serine/threonine protein kinase.
code
C41625
Contributing_Source
CTRP
Display_Name
Protein Kinase B
Legacy Concept Name
Protein_Kinase_B
Preferred_Name
Protein Kinase B
Semantic_Type
- Amino Acid, Peptide, or Protein
- Enzyme
UMLS_CUI
C0164786