OntologiesncitclassesNCIT:C82408   
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2G-1 TCR Retroviral Vector-Transduced Lymphocytes
http://purl.obolibrary.org/obo/NCIT_C82408

A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types.

Exact Synonyms
2G-1 TCR Retroviral Vector-Transduced Lymphocytes
PG13-A(F/K)-F-SGSG-T2a-B(opt)(2G-1 TCR) Retroviral Vector-Transduced Lymphocytes
class Information
code

C82408

Legacy Concept Name

_2G-1_TCR_Retroviral_Vector-Transduced_Lymphocytes

NCI_Drug_Dictionary_ID

639521

NCI_META_CUI

CL408672

PDQ_Closed_Trial_Search_ID

639521

PDQ_Open_Trial_Search_ID

639521

Preferred_Name

2G-1 TCR Retroviral Vector-Transduced Lymphocytes

Semantic_Type
  • Cell
  • Pharmacologic Substance
class Relations