OntologiesprideclassesCHEBI:75998   
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trametinibImported
http://purl.obolibrary.org/obo/CHEBI_75998

A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.

Defined bychebi
Also appears inslmefodroncidooba
Exact Synonyms
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
Related Synonyms
GSK 1120212
JTP 74057
trametinib
trametinibum
class Information
charge

0

formula

C26H23FIN5O4

has_obo_namespace

chebi_ontology

inchi

InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

inchikey

LIRYPHYGHXZJBZ-UHFFFAOYSA-N

in_subset

3_STAR

mass

615.39480

monoisotopicmass

615.07788

smiles

CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O

class Relations