A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. This entity is a specific course-dependent process. This process can constitute the course of Mitochondrial disorder.
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- Increasing HMGB1 level [mitochondrial disorder]
- decreasing mitochondrial membrane potential [Mitochondrial disorder]
- Decreasing glucose level [mitochondrial disorder]
- Increasing triol level [mitochondrial disorder]
- metabolic dysfunction of precursor metabolites and energy generation [mitochondrial disorder]
- Hypofunction of sequestering of calcium ion in ER [mitochondrial disorder]
- mitochondria fission [Mitochondrial disorder]
- cytolysis [mitochondrial disorder]
- release of cytochrome c from mitochondria [mitochondrial disorder]