OntologiesuberonclassesUBERON:0002062   
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endocardial cushion
http://purl.obolibrary.org/obo/UBERON_0002062

The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].

GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form

Also appears inhcaodhbaflopocpontaism + 18
Exact Synonyms
atrioventricular cushion
AV cushion
cardiac cushion
endocardial cushion tissue
Related Synonyms
atrioventricular canal cushion
endocardial cushions
Depicted by
Gray465.png
class Information
axiom_lost_from_external_ontology

relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]

external_definition

Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]

has_obo_namespace

uberon

homology_notes

(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG]

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