Entry status  (1)

REL

(4)

Experimental methods  (2)

Electron Microscopy

(2)

X-ray diffraction

(2)

Authors  (28)

Catterall WA

(2)

Gamal El-Din TM

(2)

Gao S

(2)

Tang L

(2)

Yan N

(2)

Zheng N

(2)

Chen J

(1)

El-Din TM

(1)

Fan X

(1)

Gamal EL-Din TM

(1)

Huang G

(1)

Huang J

(1)

Jin X

(1)

Lenaeus MJ

(1)

Li Z

(1)

Liu L

(1)

Pan X

(1)

Pryde DC

(1)

Scheuer T

(1)

Song C

(1)

Swanson TM

(1)

Wang Y

(1)

Wang Z

(1)

Wu T

(1)

Xue L

(1)

Yao X

(1)

Yu Y

(1)

Zheng Y

(1)

Homo / hetero assembly  (2)

hetero

(2)

homo

(2)

Assembly composition  (2)

protein structure

(2)

protein/protein complex

(2)

Assembly polymer count  (2)

tetramer

(3)

trimer

(1)

Resolution distribution

2.5 - 3

(3)

3.0 - 3.5

(1)

Release year distribution

2015 - 2020

(3)

2020 - 2025

(2)

Journal  (4)

Angew Chem Int Ed Engl

(1)

Cell

(1)

Mol Pharmacol

(1)

Nature

(1)

Organism superkingdom  (2)

Bacteria

(2)

Eukaryota

(2)

Organism name  (4)

Aliarcobacter butzleri RM4018

(2)

Dendroaspis polylepis polylepis

(1)

Homo sapiens

(1)

Oryctolagus cuniculus

(1)

Molecule name  (23)

Ion transport domain-containing protein

(2)

Ion transport protein

(2)

Voltage-dependent calcium channel subunit alpha-2-1

(2)

Voltage-dependent calcium channel subunit alpha-2/delta-1

(2)

Voltage-dependent calcium channel subunit delta-1

(2)

Voltage-gated calcium channel subunit alpha-2/delta-1

(2)

CAB3

(1)

CaS

(1)

Calciseptin

(1)

Calciseptine

(1)

Calcium channel voltage-dependent subunit beta 3

(1)

Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle

(1)

Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle

(1)

DHPR

(1)

Dihydropyridine receptor alpha-1S subunit

(1)

Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma

(1)

L-type calcium channel blocker

(1)

Voltage-dependent L-type calcium channel subunit alpha-1C

(1)

Voltage-dependent L-type calcium channel subunit alpha-1S

(1)

Voltage-dependent L-type calcium channel subunit beta-3

(1)

Voltage-dependent calcium channel gamma-1 subunit

(1)

Voltage-gated calcium channel subunit alpha Cav1.1

(1)

Voltage-gated calcium channel subunit alpha Cav1.2

(1)

Molecule type  (1)

Protein

(4)

Gene names  (17)

Abu_1752

(2)

CACNA2D1

(2)

CACNL2A

(2)

CCHL2A

(2)

CACH1

(1)

CACH2

(1)

CACN2

(1)

CACNA1C

(1)

CACNA1S

(1)

CACNB3

(1)

CACNG1

(1)

CACNL1A1

(1)

CACNL1A3

(1)

CACNLB3

(1)

CACNLG

(1)

CCHL1A1

(1)

MHS3

(1)

Interacting Molecules  (6)

Voltage-dependent calcium channel subunit alpha-2/delta-1

(2)

Calciseptin

(1)

Voltage-dependent L-type calcium channel subunit alpha-1C

(1)

Voltage-dependent L-type calcium channel subunit alpha-1S

(1)

Voltage-dependent L-type calcium channel subunit beta-3

(1)

Voltage-dependent calcium channel gamma-1 subunit

(1)

Interacting ligands  (12)

6UB : amlodipine

(4)

CA : CALCIUM ION

(4)

3PE : 1,2-Distearoyl-sn-glycerophosphoethanolamine

(2)

CLR : CHOLESTEROL

(1)

D6C : [(2~{S},3~{R})-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxidanylidene-2,3-dihydro-1,5-benzothiazepin-3-yl] ethanoate

(1)

G3P : SN-GLYCEROL-3-PHOSPHATE

(1)

LPC : [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE

(1)

MC3 : 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE

(1)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(1)

PC1 : 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE

(1)

POV : (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate

(1)

PT5 : [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate

(1)

Biological function  (17)

metal ion binding

(4)

monoatomic ion channel activity

(4)

calcium channel activity

(2)

calcium channel regulator activity

(2)

calmodulin binding

(2)

high voltage-gated calcium channel activity

(2)

identical protein binding

(2)

monoatomic cation channel activity

(2)

protein binding

(2)

voltage-gated calcium channel activity

(2)

voltage-gated sodium channel activity

(2)

alpha-actinin binding

(1)

ion channel regulator activity

(1)

toxin activity

(1)

transmembrane transporter binding

(1)

voltage-gated calcium channel activity involved in AV node cell action potential

(1)

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

(1)

Biological process  (37)

monoatomic ion transmembrane transport

(4)

monoatomic ion transport

(4)

transmembrane transport

(4)

calcium ion import across plasma membrane

(2)

calcium ion transmembrane transport

(2)

calcium ion transport

(2)

monoatomic cation transmembrane transport

(2)

positive regulation of muscle contraction

(2)

sodium ion transmembrane transport

(2)

T cell receptor signaling pathway

(1)

calcium ion transmembrane transport via high voltage-gated calcium channel

(1)

calcium ion transport into cytosol

(1)

camera-type eye development

(1)

cardiac conduction

(1)

cardiac muscle cell action potential involved in contraction

(1)

cell communication by electrical coupling involved in cardiac conduction

(1)

cellular response to caffeine

(1)

chemical synaptic transmission

(1)

embryonic forelimb morphogenesis

(1)

heart development

(1)

immune system development

(1)

membrane depolarization during AV node cell action potential

(1)

membrane depolarization during atrial cardiac muscle cell action potential

(1)

membrane depolarization during cardiac muscle cell action potential

(1)

modulation of process of another organism

(1)

muscle contraction

(1)

positive regulation of adenylate cyclase activity

(1)

positive regulation of cytosolic calcium ion concentration

(1)

positive regulation of high voltage-gated calcium channel activity

(1)

protein localization to plasma membrane

(1)

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

(1)

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

(1)

regulation of heart rate by cardiac conduction

(1)

regulation of membrane repolarization during action potential

(1)

regulation of ryanodine-sensitive calcium-release channel activity

(1)

regulation of ventricular cardiac muscle cell action potential

(1)

release of sequestered calcium ion into cytosol

(1)

Biological cell component  (21)

membrane

(4)

plasma membrane

(4)

L-type voltage-gated calcium channel complex

(2)

T-tubule

(2)

monoatomic ion channel complex

(2)

sarcolemma

(2)

voltage-gated calcium channel complex

(2)

voltage-gated sodium channel complex

(2)

Z disc

(1)

cell projection

(1)

cilium

(1)

cytoplasm

(1)

cytosol

(1)

dendrite

(1)

extracellular region

(1)

nucleoplasm

(1)

perikaryon

(1)

postsynaptic density

(1)

postsynaptic density membrane

(1)

postsynaptic membrane

(1)

synapse

(1)

Pfam accession / name  (12)

PF00520 : Ion_trans

(4)

PF08016 : PKD_channel

(4)

PF00092 : VWA

(2)

PF08399 : VWA_N

(2)

PF08473 : VGCC_alpha2

(2)

PF08763 : Ca_chan_IQ

(2)

PF16885 : CAC1F_C

(2)

PF16905 : GPHH

(2)

PF00625 : Guanylate_kin

(1)

PF12052 : VGCC_beta4Aa_N

(1)

PF13903 : Claudin_2

(1)

PF21947 : Toxin_cobra-type

(1)

Diffraction protocol  (1)

Single wavelength

(2)

Diffraction radiation source type  (1)

Synchrotron

(2)

Diffraction source  (1)

ALS BEAMLINE 8.2.1

(2)

Synchrotron site  (1)

ALS

(2)

Diffraction detector type  (1)

CCD

(2)

Refinement software  (2)

PHENIX

(2)

REFMAC

(1)

Representative Structures

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