Compound three letter code : FO9
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (2)
X-ray diffraction
(3)
Electron Microscopy
(1)
 
Authors  (18)
Angeli A
(2)
Ferraroni M
(2)
Supuran CT
(2)
Ahmad MS
(1)
Akbar Z
(1)
Che T
(1)
Choudhary MI
(1)
He F
(1)
Kalam N
(1)
Meyerowitz JG
(1)
Panova O
(1)
Papasergi-Scott MM
(1)
Peroto MC
(1)
Rasheed S
(1)
Robertson MJ
(1)
Seven AB
(1)
Shah N
(1)
Skiniotis G
(1)
 
Homo / hetero assembly  (2)
homo
(3)
hetero
(1)
 
Assembly composition  (2)
protein structure
(3)
protein/protein complex
(1)
 
Assembly polymer count  (2)
monomer
(3)
tetramer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(1)
2.0 - 2.5
(1)
2.5 - 3
(1)
 
Release year distribution
2015 - 2020
(2)
2020 - 2025
(2)
 
Journal  (3)
ACS Med Chem Lett
(2)
Biochem Biophys Res Commun
(1)
Nat Struct Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (3)
Homo sapiens
(3)
Bos taurus
(1)
synthetic construct
(1)
 
Molecule name  (36)
Alpha-trypsin chain 1
(1)
Alpha-trypsin chain 2
(1)
Anionic trypsin I
(1)
Anionic trypsin-I
(1)
Beta-trypsin
(1)
CA-I
(1)
CA-II
(1)
CAB
(1)
CAC
(1)
Carbonate dehydratase I
(1)
Carbonate dehydratase II
(1)
Carbonic anhydrase 1
(1)
Carbonic anhydrase 2
(1)
Carbonic anhydrase B
(1)
Carbonic anhydrase C
(1)
Carbonic anhydrase I
(1)
Carbonic anhydrase II
(1)
Cationic trypsin
(1)
Cyanamide hydratase CA1
(1)
Cyanamide hydratase CA2
(1)
Gastric receptor I
(1)
H2R
(1)
HH2R
(1)
Histamine H2 receptor
(1)
IG-heavy chain
(1)
IG-light kappa chain
(1)
K-OR-1
(1)
KOR-1
(1)
Kappa-type opioid receptor
(1)
NabFab HC
(1)
NabFab LC
(1)
Nanobody 6M
(1)
Pretrypsinogen I
(1)
Serine protease 1
(1)
Trypsin I
(1)
Trypsin-I
(1)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (9)
CA1
(1)
CA2
(1)
HRH2
(1)
OPRK
(1)
OPRK1
(1)
PRSS1
(1)
TRP1
(1)
TRY1
(1)
TRYP1
(1)
 
Interacting Molecules  (5)
Histamine H2 receptor
(1)
Kappa-type opioid receptor
(1)
NabFab HC
(1)
NabFab LC
(1)
Nanobody 6M
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Crystal structure of trypsin-famotidine complex at 2.10 Angstroms resolution
Ahmad MS, Kalam N, Akbar Z, Rasheed S, Choudhary MI
Biochem Biophys Res Commun (2024) [PMID: 39216203  ]
Source organism: Bos taurus  
Assembly composition: protein only structure
Bound ligands: CA    CA    FO9    SO4    CL   
Assembly name: Serine protease 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133319 (Preferred)   search this ID
PDBe-KB: P00760   
X-ray diffraction
2.1Å resolution
Released: 18 Sep 2024
Model geometry
Fit model/data
8iyv
8iyv
8iyv
CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab
Robertson MJ, Skiniotis G
Nat Struct Mol Biol (2022) [PMID: 36396979  ]
Assembly composition: protein/protein complex
Bound ligands: FO9   
Assembly name: Histamine H2 receptor, Kappa-type opioid receptor and IG-heavy chain and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-276181 (Preferred)   search this ID
PDBe-KB: P41145    P25021   
Electron Microscopy
3Å resolution
Released: 29 Jun 2022
Model geometry
Fit model/data
Data not analysed
7ul3
7ul3
7ul3
Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine
Ferraroni M, Supuran CT, Angeli A
ACS Med Chem Lett (2018) [PMID: 30344913  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    ZN    FO9    ZN   
Assembly name: Carbonic anhydrase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133680 (Preferred)   search this ID
PDBe-KB: P00915   
X-ray diffraction
1.69Å resolution
Released: 28 Nov 2018
Model geometry
Fit model/data
6g3v
6g3v
6g3v
Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine
Ferraroni M, Supuran CT, Angeli A
ACS Med Chem Lett (2018) [PMID: 30344913  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    ZN    FO9    ZN   
Assembly name: Carbonic anhydrase 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133681 (Preferred)   search this ID
PDBe-KB: P00918   
X-ray diffraction
1.01Å resolution
Released: 28 Nov 2018
Model geometry
Fit model/data
6g3q
6g3q
6g3q
Entries 1 to 4 of 4
Entries 1 to 4 of 4