Compound three letter code : RIS
 
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REL
(19)
 
Experimental methods  (3)
X-ray diffraction
(19)
Hybrid
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(2)
 
Authors  (73)
Oppermann U
(11)
Dunford JE
(10)
Ebetino FH
(9)
Kavanagh KL
(9)
Barnett BL
(7)
Muniz JRC
(7)
Russell RGG
(7)
Tsoumpra MK
(7)
Walter RL
(7)
Evdokimov A
(4)
Pilka E
(4)
Structural Genomics Consortium (SGC)
(4)
Sundstrom M
(4)
von Delft F
(4)
Christianson DW
(3)
Edwards A
(3)
Kwaasi AA
(3)
Arrowsmith C
(2)
Arrowsmith CH
(2)
Evdokimov AG
(2)
Gardner SM
(2)
Guo K
(2)
Kusaka K
(2)
Kwaasi A
(2)
Mizuguchi M
(2)
Niimura N
(2)
Oldfield E
(2)
Ostermann A
(2)
Ronnebaum TA
(2)
Russell RG
(2)
Schrader TE
(2)
Tanaka I
(2)
Weigelt J
(2)
Yokoyama T
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Amzel LM
(1)
Arrowood MJ
(1)
Artz JD
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Bochkarev A
(1)
Brooun A
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Broun A
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Cao R
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Chruszcz M
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Docampo R
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Dong A
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Dougan DR
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Dunford J
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Eaton SA
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Edwards AM
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Finn J
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Gabelli SB
(1)
Gileadi O
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Hosfield DJ
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Hozjan V
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Hui R
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Kavanaugh KL
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Knapp S
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Kozieradski I
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Lew J
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Liu Y-L
(1)
Liu YL
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McLellan JS
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Minor W
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Montalvetti A
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Pilka ES
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Rogers MJ
(1)
Swanson RV
(1)
Tari LW
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Von Delft F
(1)
Von delft F
(1)
Wang Y
(1)
Wu X
(1)
Zhang Y
(1)
Zhao Y
(1)
 
Homo / hetero assembly  (1)
homo
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Assembly composition  (1)
protein structure
(19)
 
Assembly polymer count  (2)
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(15)
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(4)
 
Resolution distribution
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(5)
1.5 - 2
(9)
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(5)
 
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(10)
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(3)
 
Journal  (8)
To be published
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J Med Chem
(2)
ACS Med Chem Lett
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Proc Natl Acad Sci U S A
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Proteins
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Representative Structures
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Entries 1 to 10 of 19
Entries 1 to 10 of 19
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Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate
Yokoyama T, Mizuguchi M, Ostermann A, Kusaka K, Niimura N, Schrader TE, Tanaka I
J Med Chem (2015) [PMID: 26314394  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    MG   
Assembly name: Farnesyl pyrophosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146902 (Preferred)   search this ID
PDBe-KB: P14324   
X-ray diffraction, Neutron Diffraction, Hybrid
1.402Å resolution
Released: 14 Oct 2015
Model geometry
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Data not analysed
5cg5
5cg5
5cg5
Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate
Yokoyama T, Mizuguchi M, Ostermann A, Kusaka K, Niimura N, Schrader TE, Tanaka I
J Med Chem (2015) [PMID: 26314394  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: IPE    MG    RIS    RIS    MG    IPE   
Assembly name: Farnesyl pyrophosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146902 (Preferred)   search this ID
PDBe-KB: P14324   
X-ray diffraction, Neutron Diffraction, Hybrid
1.7Å resolution
Released: 14 Oct 2015
Model geometry
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Data not analysed
5cg6
5cg6
5cg6
F96M epi-isozizaene synthase: complex with 3 Mg2+ and risedronate
Ronnebaum TA, Gardner SM, Christianson DW
Biochemistry (2020) [PMID: 33270439  ]
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    SO4    MG   
Assembly name: Epi-isozizaene synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-191758 (Preferred)   search this ID
PDBe-KB: Q9K499   
X-ray diffraction
1.5Å resolution
Released: 16 Dec 2020
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7kjd
7kjd
7kjd
Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and risedronate
Ronnebaum TA, Gardner SM, Christianson DW
Biochemistry (2020) [PMID: 33270439  ]
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    SO4    MG   
Assembly name: Epi-isozizaene synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-191758 (Preferred)   search this ID
PDBe-KB: Q9K499   
X-ray diffraction
2.2Å resolution
Released: 16 Dec 2020
Model geometry
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7kj9
7kj9
7kj9
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Tsoumpra MK, Muniz JRC, Barnett BL, Kwaasi AA, Pilka ES, Kavanagh KL, Evdokimov A, Walter RL, Ebetino FH, von Delft F, Oppermann U, Russell RGG, Dunford JE
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    SO4    MG   
Assembly name: Farnesyl pyrophosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146902 (Preferred)   search this ID
PDBe-KB: P14324    P14324   
X-ray diffraction
1.98Å resolution
Released: 18 Mar 2015
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4q23
4q23
4q23
T. Brucei Farnesyl Diphosphate Synthase Complexed with Risedronate
Cao R, Liu Y-L, Oldfield E
ACS Med Chem Lett (2015) [PMID: 25815158  ]
Source organism: Trypanosoma brucei  
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    MG   
Assembly name: Farnesyl pyrophosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183122 (Preferred)   search this ID
PDBe-KB: Q86C09   
X-ray diffraction
2Å resolution
Released: 15 Apr 2015
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4rxd
4rxd
4rxd
Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate.
Chruszcz M, Artz JD, Dong A, Dunford J, Lew J, Zhao Y, Kozieradski I, Kavanaugh KL, Oppermann U, Sundstrom M, Weigelt J, Edwards AM, Arrowsmith CH, Bochkarev A, Hui R, Minor W, Structural Genomics Consortium (SGC)
Chem Biol (2008) [PMID: 19101474  ]
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    MG   
Assembly name: Putative farnesyl pyrophosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-176918 (Preferred)   search this ID
PDBe-KB: Q5CR09   
X-ray diffraction
2.42Å resolution
Released: 12 Dec 2006
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2o1o
2o1o
2o1o
Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate
Hosfield DJ, Zhang Y, Dougan DR, Brooun A, Tari LW, Swanson RV, Finn J
J Biol Chem (2004) [PMID: 14672944  ]
Source organism: Escherichia coli  
Assembly composition: protein only structure
Bound ligands: IPE    MG    RIS    RIS    MG    IPE   
Assembly name: Farnesyl diphosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149843 (Preferred)   search this ID
PDBe-KB: P22939   
X-ray diffraction
1.95Å resolution
Released: 2 Mar 2004
Model geometry
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Data not deposited
1rqj
1rqj
1rqj
Structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with risedronate, dmapp and mg+2
Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM
Proteins (2006) [PMID: 16288456  ]
Source organism: Trypanosoma cruzi  
Assembly composition: protein only structure
Bound ligands: DMA    MG    RIS    RIS    SO4    MG    DMA   
Assembly name: Farnesyl diphosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-186689 (Preferred)   search this ID
PDBe-KB: Q8WS26   
X-ray diffraction
1.95Å resolution
Released: 20 Dec 2005
Model geometry
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Data not deposited
1yhl
1yhl
1yhl
Human farnesyl diphosphate synthase complexed with Mg and risedronate
Kavanagh KL, Guo K, Von Delft F, Arrowsmith C, Sundstrom M, Edwards A, Oppermann U, Structural Genomics Consortium (SGC)
Proc Natl Acad Sci U S A (2006) [PMID: 16684881  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    RIS    RIS    MG    PO4   
Assembly name: Farnesyl pyrophosphate synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146902 (Preferred)   search this ID
PDBe-KB: P14324   
X-ray diffraction
2Å resolution
Released: 1 Mar 2005
Model geometry
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1yv5
1yv5
1yv5
Entries 1 to 10 of 19
Entries 1 to 10 of 19