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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(15)
Electron Microscopy
(1)
Authors
(149)
de Oliveira Neto M
(3)
Becker CF
(2)
Cargnelutti MT
(2)
Dos Santos JI
(2)
Dreyer TR
(2)
Fontes MRM
(2)
Gallacci M
(2)
Giesel GM
(2)
Lima LM
(2)
Lima LMTR
(2)
Marques AF
(2)
Monteiro RQ
(2)
Plotnikov AN
(2)
Polikarpov I
(2)
Queiroz Monteiro R
(2)
Salvador GHM
(2)
Structural Genomics Consortium (SGC)
(2)
Velazquez-Campoy A
(2)
Verli H
(2)
Airoldi C
(1)
Allali-Hassani A
(1)
Antoshenko T
(1)
Arni RK
(1)
Arrowsmith CH
(1)
Arruda EZ
(1)
Auld DS
(1)
Bernardini A
(1)
Bingman CA
(1)
Bochkarev A
(1)
Bolognesi M
(1)
Burgie ES
(1)
Calil-Elias S
(1)
Calil-Eliás S
(1)
Camilloni C
(1)
Cavalcante WL
(1)
Cavalcante WLG
(1)
Center for Eukaryotic Structural Genomics (CESG)
(1)
Chaves-Sanjuan A
(1)
Cheng J
(1)
Ding W
(1)
Dolfini D
(1)
Dong A
(1)
Edwards AM
(1)
Fontes MR
(1)
Fothergill-Gilmore LA
(1)
Gandin CA
(1)
Gao GF
(1)
Germani F
(1)
Gnesutta N
(1)
Go ML
(1)
Gomes AAS
(1)
Gutierrez JM
(1)
Gutiérrez JM
(1)
Halg S
(1)
Hashemi H
(1)
Hempelmann A
(1)
Hälg S
(1)
Jakoncic J
(1)
Jeffrey P
(1)
Jeffrey PD
(1)
Jiao L
(1)
Jin C
(1)
Kim Y
(1)
Kini RM
(1)
Knapp S
(1)
Kraemer A
(1)
Kramer D
(1)
Lapi M
(1)
Li C
(1)
Li D
(1)
Li J
(1)
Liang M
(1)
Liu ZJ
(1)
Lomonte B
(1)
Loppnau P
(1)
Luan CH
(1)
Mantovani R
(1)
Martinez AB
(1)
Maser P
(1)
Mastrangelo E
(1)
Matioli FF
(1)
McNae IW
(1)
Melo PA
(1)
Michels PA
(1)
Michels PAM
(1)
Milani M
(1)
Min J
(1)
Min JR
(1)
Morgan HP
(1)
Morohashi K
(1)
Murakami MT
(1)
Mäser P
(1)
Nardini M
(1)
Nardone V
(1)
Niu F
(1)
Nowicki MW
(1)
Ouyang S
(1)
Papavasiliou FN
(1)
Pasqualato S
(1)
Peng Q
(1)
More...
Homo / hetero assembly
(2)
homo
(12)
hetero
(4)
Assembly composition
(2)
protein structure
(12)
protein/protein complex
(4)
Assembly polymer count
(6)
dimer
(5)
monomer
(4)
pentamer
(2)
tetramer
(2)
trimer
(2)
octamer
(1)
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(5)
2.0 - 2.5
(8)
2.5 - 3
(1)
3.0 - 3.5
(1)
Release year distribution
2000 - 2005
(1)
2005 - 2010
(7)
2010 - 2015
(5)
2015 - 2020
(3)
2020 - 2025
(4)
Journal
(13)
Biochim Biophys Acta
(2)
J Mol Biol
(2)
To be published
(2)
Acta Crystallogr D Biol Crystallogr
(1)
Biophys J
(1)
Cells
(1)
Chem Biol
(1)
J Biol Chem
(1)
J Virol
(1)
Nat Microbiol
(1)
Nature
(1)
Sci Rep
(1)
Structure
(1)
Macromolecules
Organism superkingdom
(2)
Eukaryota
(13)
Viruses
(3)
Organism name
(11)
Homo sapiens
(4)
Bothrops moojeni
(2)
Mus musculus
(2)
Arabidopsis thaliana
(1)
Bothrops asper
(1)
Ebola virus
(1)
Echis carinatus
(1)
Leishmania mexicana
(1)
Murine norovirus 1
(1)
Phlebovirus JS2010-018
(1)
Trypanosoma brucei rhodesiense
(1)
Molecule name
(88)
svPLA2 homolog
(4)
Activation peptide fragment 1
(2)
Activation peptide fragment 2
(2)
Basic phospholipase A2 homolog 2
(2)
Coagulation factor II
(2)
Prothrombin
(2)
RNA-directed RNA polymerase
(2)
Thrombin heavy chain
(2)
Thrombin light chain
(2)
3C-like protease
(1)
3CLpro
(1)
52 kDa Ro protein
(1)
52 kDa ribonucleoprotein autoantigen Ro/SS-A
(1)
Basic phospholipase A2 homolog 1
(1)
Basic phospholipase A2 homolog BomoTx
(1)
Basic phospholipase A2 homolog MjTX-I
(1)
Basic phospholipase A2 homolog ecarpholin S
(1)
Basic phospholipase A2 homolog myotoxin II
(1)
Basp-II
(1)
CAAT box DNA-binding protein subunit B
(1)
CAAT box DNA-binding protein subunit C
(1)
Calicivirin
(1)
Chromobox protein homolog 7
(1)
E3 ubiquitin-protein ligase TRIM21
(1)
Ecs-S49
(1)
G-N7-MTase
(1)
GDP polyribonucleotidyltransferase
(1)
GTP phosphohydrolase
(1)
Genome polyprotein
(1)
Large structural protein
(1)
Lys49 Mt-II
(1)
M-VI
(1)
MjTX-II
(1)
MtxII
(1)
Myotoxin I
(1)
Myotoxin II
(1)
N1-2'-O-MTase
(1)
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(1)
NF-YB
(1)
NF-YC
(1)
NS1
(1)
NS1-2
(1)
NS1.2
(1)
NS1/2
(1)
NS2
(1)
NS3
(1)
NS4
(1)
NS5
(1)
NS6
(1)
NS7
(1)
NTPase
(1)
Nuclear transcription factor Y subunit B
(1)
Nuclear transcription factor Y subunit C
(1)
Nuclear transcription factor Y subunit beta
(1)
Nuclear transcription factor Y subunit gamma
(1)
Nucleocapsid protein
(1)
Nucleoprotein
(1)
PHE-PRO-ARG
(1)
PK
(1)
PPACK active site thrombin inhibitor
(1)
PRNTase
(1)
Polymerase
(1)
Polymerase cofactor VP35
(1)
Protein L
(1)
Protein N
(1)
Protein RDM1
(1)
Protein RNA-directed DNA methylation 1
(1)
Protein p20
(1)
Protein p37
(1)
Pyruvate kinase
(1)
RNA-directed RNA polymerase L
(1)
RdRp
(1)
Regulatory protein SIR2 homolog 5
(1)
Replicase
(1)
Ro(SS-A)
(1)
SIR2-like protein 5
(1)
SS-A
(1)
Sjoegren syndrome type A antigen
(1)
Transactivator HSM-1/2
(1)
Transcriptase
(1)
Tripartite motif-containing protein 21
(1)
VP35
(1)
VPg
(1)
Variant surface glycoprotein Sur
(1)
Viral genome-linked protein
(1)
mRNA (guanine-N(7)-)-methyltransferase
(1)
mRNA (nucleoside-2'-O-)-methyltransferase
(1)
p41
(1)
Molecule type
(1)
Protein
(16)
Gene names
(20)
F2
(2)
At3g22680
(1)
Cbx7
(1)
D15Ertd417e
(1)
HAP3
(1)
L
(1)
MWI23.5
(1)
NFYB
(1)
NFYC
(1)
NP
(1)
ORF1
(1)
PYK
(1)
RDM1
(1)
Ro52
(1)
SIR2L5
(1)
SIRT5
(1)
Ssa1
(1)
Trim21
(1)
VP35
(1)
VSGsur
(1)
Interacting Molecules
(8)
Thrombin heavy chain
(2)
Thrombin light chain
(2)
Nuclear transcription factor Y subunit beta
(1)
Nuclear transcription factor Y subunit gamma
(1)
PHE-PRO-ARG
(1)
PPACK active site thrombin inhibitor
(1)
Polymerase cofactor VP35
(1)
RNA-directed RNA polymerase L
(1)
Interacting ligands
(15)
SVR : 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON
IC ACID
(16)
GOL : GLYCEROL
(2)
PE4 : 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
(2)
SO4 : SULFATE ION
(2)
1PE : PENTAETHYLENE GLYCOL
(1)
BMA : beta-D-mannopyranose
(1)
CL : CHLORIDE ION
(1)
EDO : 1,2-ETHANEDIOL
(1)
IPA : ISOPROPYL ALCOHOL
(1)
K : POTASSIUM ION
(1)
MAN : alpha-D-mannopyranose
(1)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(1)
P33 : 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL
(1)
PTK : pyrene-1,3,6,8-tetrasulfonic acid
(1)
ZN : ZINC ION
(1)
Function and Biology
EC number / name
(9)
2.7.7.48 : RNA-directed RNA polymerase
(2)
3.1.1.4 : Phospholipase A(2)
(2)
3.4.21.5 : Thrombin
(2)
2.1.1.375 : NNS virus cap methyltransferase
(1)
2.3.2.27 : RING-type E3 ubiquitin transferase
(1)
2.7.1.40 : Pyruvate kinase
(1)
2.7.7.88 : GDP polyribonucleotidyltransferase
(1)
3.4.22.66 : Calicivirin
(1)
3.6.1.15 : Nucleoside-triphosphate phosphatase
(1)
Biological function
(33)
calcium ion binding
(6)
calcium-dependent phospholipase A2 activity
(4)
phospholipase A2 activity
(4)
phospholipid binding
(4)
ATP binding
(3)
toxin activity
(3)
DNA binding
(2)
RNA binding
(2)
RNA-directed RNA polymerase activity
(2)
catalytic activity
(2)
nucleotide binding
(2)
serine-type endopeptidase activity
(2)
transferase activity
(2)
5'-3' RNA polymerase activity
(1)
DNA-binding transcription activator activity, RNA polymerase II-specific
(1)
GTPase activity
(1)
NAD+ binding
(1)
helicase activity
(1)
heparin binding
(1)
hydrolase activity
(1)
kinase activity
(1)
mRNA 5'-cap (guanine-N7-)-methyltransferase activity
(1)
magnesium ion binding
(1)
metal ion binding
(1)
methyltransferase activity
(1)
nucleotidyltransferase activity
(1)
potassium ion binding
(1)
protein binding
(1)
protein heterodimerization activity
(1)
protein-malonyllysine demalonylase activity
(1)
protein-succinyllysine desuccinylase activity
(1)
pyruvate kinase activity
(1)
sequence-specific DNA binding
(1)
Biological process
(27)
arachidonate secretion
(4)
lipid catabolic process
(4)
negative regulation of T cell proliferation
(4)
phospholipid metabolic process
(4)
modulation of process of another organism
(3)
blood coagulation
(2)
defense response to bacterium
(2)
proteolysis
(2)
7-methylguanosine mRNA capping
(1)
DNA-templated transcription
(1)
RNA 5'-cap (guanine-N7)-methylation
(1)
RNA-templated transcription
(1)
defense response to fungus
(1)
gene silencing by siRNA-directed DNA methylation
(1)
glycolytic process
(1)
killing of cells of another organism
(1)
mRNA processing
(1)
methylation
(1)
nucleobase-containing compound metabolic process
(1)
obsolete DNA methylation
(1)
regulation of DNA-templated transcription
(1)
siRNA processing
(1)
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
(1)
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
(1)
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
(1)
symbiont-mediated suppression of host toll-like receptor signaling pathway
(1)
viral RNA genome replication
(1)
Biological cell component
(14)
extracellular region
(6)
host cell cytoplasm
(2)
nucleus
(2)
virion component
(2)
CCAAT-binding factor complex
(1)
PRC1 complex
(1)
RNA polymerase V complex
(1)
host cell Golgi apparatus
(1)
host cell endoplasmic reticulum-Golgi intermediate compartment
(1)
host cell nucleus
(1)
nucleoplasm
(1)
ribonucleoprotein complex
(1)
viral capsid
(1)
viral nucleocapsid
(1)
Sequence and Structure classification
SCOP fold
(2)
DHS-like NAD/FAD-binding domain
(1)
Phospholipase A2, PLA2
(1)
SCOP family
(2)
Sir2 family of transcriptional regulators
(1)
Vertebrate phospholipase A2
(1)
CATH class
(4)
Mainly Alpha
(6)
Mainly Beta
(4)
Alpha Beta
(3)
Special
(1)
CATH topology
(12)
Phospholipase A2
(4)
Thrombin, subunit H
(2)
Alpha-Beta Plaits
(1)
Four Helix Bundle (Hemerythrin (Met), subunit A)
(1)
M1 Pyruvate Kinase; Domain 3
(1)
Mitochondrial Import Receptor Subunit Tom20; Chain A
(1)
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
(1)
Pyruvate Kinase; Chain: A, domain 1
(1)
Rossmann fold
(1)
SIR2/SIRT2 'Small Domain'
(1)
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
(1)
TIM Barrel
(1)
Pfam accession / name
(17)
PF00068 : Phospholip_A2_1
(4)
PF00089 : Trypsin
(2)
PF09396 : Thrombin_light
(2)
PF00125 : Histone
(1)
PF00224 : PK
(1)
PF00385 : Chromo
(1)
PF00622 : SPRY
(1)
PF00680 : RdRP_1
(1)
PF00808 : CBFD_NFYB_HMF
(1)
PF00946 : Mononeg_RNA_pol
(1)
PF02097 : Filo_VP35
(1)
PF02146 : SIR2
(1)
PF02887 : PK_C
(1)
PF05733 : Tenui_N
(1)
PF09187 : RdDM_RDM1
(1)
PF13765 : PRY
(1)
PF14318 : Mononeg_mRNAcap
(1)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(15)
Diffraction radiation source type
(2)
Synchrotron
(12)
Rotating anode
(3)
Diffraction source
(12)
DIAMOND BEAMLINE I03
(2)
LNLS BEAMLINE D03B-MX1
(2)
LNLS BEAMLINE W01B-MX2
(2)
APS BEAMLINE 23-ID-D
(1)
ESRF BEAMLINE ID14-1
(1)
ESRF BEAMLINE ID29
(1)
NSLS BEAMLINE X6A
(1)
PHOTON FACTORY BEAMLINE BL-17A
(1)
RIGAKU
(1)
RIGAKU RUH3R
(1)
RIGAKU ULTRAX 18
(1)
SLS BEAMLINE X06DA
(1)
Synchrotron site
(7)
LNLS
(4)
Diamond
(2)
ESRF
(2)
APS
(1)
NSLS
(1)
Photon Factory
(1)
SLS
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 16
Select all entries on this page
NF-Y bound to suramin inhibitor
Nardone V, Chaves-Sanjuan A, Lapi M, Nardini M
Cells
(2020)
[PMID: 33138093 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Nuclear transcription factor Y
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-150406 (Preferred)
search this ID
Crystal structure of Myotoxin I (MjTX-I) from Bothrops moojeni complexed to inhibitor suramin
Salvador GHM, Fontes MRM
Sci Rep
(2018)
[PMID: 29985425 ]
Source organism: Bothrops moojeni
Assembly composition: protein only structure
Assembly name:
Basic phospholipase A2 homolog MjTX-I
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-160603 (Preferred)
search this ID

Crystal structure of TRIM21 PRY-SPRY domain bound to Suramin
Kim Y, Knapp S, Kraemer A, Structural Genomics Consortium (SGC)
To be published
Source organism: Mus musculus
Assembly composition: protein only structure
Assembly name:
E3 ubiquitin-protein ligase TRIM21
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-280644 (Preferred)
search this ID

Variant Surface Glycoprotein VSGsur bound to suramin
Zeelen JP, Straaten van M, Stebbins CE, Jeffrey P
Nat Microbiol
(2021)
[PMID: 33462435 ]
Source organism: Trypanosoma brucei rhodesiense
Assembly composition: protein only structure
Carbohydrate polymer components:
Molecule 1 -
BMA(1), MAN(6), NAG(2)
Molecule 2 -
BMA(1), MAN(6), NAG(2)
Assembly name:
Variant surface glycoprotein Sur
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-104124 (Preferred)
search this ID

Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin
Min JR, Antoshenko T, Allali-Hassani A, Dong A, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)
Structure
(2007)
[PMID: 17355872 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-192679 (Preferred)
search this ID

Crystal structure of Bothrops asper myotoxin II complexed with the anti-trypanosomal drug suramin
Murakami MT, Arruda EZ, Melo PA, Martinez AB, Calil-Elias S, Tomaz MA, Lomonte B, Gutierrez JM, Arni RK
J Mol Biol
(2005)
[PMID: 15961104 ]
Source organism: Bothrops asper
Assembly composition: protein only structure
Assembly name:
Basic phospholipase A2 homolog 2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-150258 (Preferred)
search this ID

Crystal structure of gene product from Arabidopsis thaliana At3g22680 with bound suramin
Burgie ES, Bingman CA, Wesenberg GE, Phillips Jr GN, Center for Eukaryotic Structural Genomics (CESG)
To be published
Source organism: Arabidopsis thaliana
Assembly composition: protein only structure
Assembly name:
Protein RDM1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-192318 (Preferred)
search this ID

The structure of EBOV L-VP35 in complex with suramin
Shi Y, Yuan B, Peng Q
Nature
(2022)
[PMID: 36171293 ]
Source organism: Ebola virus
Assembly composition: protein/protein complex
Assembly name:
RNA-directed RNA polymerase L and Polymerase cofactor VP35
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-103299 (Preferred)
search this ID
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin
Ren C, Zhou MM
Chem Biol
(2015)
[PMID: 25660273 ]
Source organism: Mus musculus
Assembly composition: protein only structure
Assembly name:
Chromobox protein homolog 7
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-186570 (Preferred)
search this ID

Pentameric SFTSVN with suramin
Jiao L, Ouyang S, Liang M, Niu F, Shaw N, Wu W, Ding W, Jin C, Zhu Y, Zhang F, Wang T, Li C, Zuo X, Luan CH, Li D, Liu ZJ
J Virol
(2013)
[PMID: 23576501 ]
Source organism: Phlebovirus JS2010-018
Assembly composition: protein only structure
Assembly name:
Nucleoprotein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-125168 (Preferred)
search this ID

Entries 1 to 10 of 16