Entry status  (1)

REL

(8)

Experimental methods  (1)

X-ray diffraction

(8)

Authors  (29)

Schiffer CA

(7)

Ali A

(5)

Romano KP

(4)

Soumana D

(4)

Aydin C

(3)

Cao H

(3)

Deveau LM

(3)

Huang W

(3)

Newton A

(3)

Ozen A

(3)

Petropoulos CJ

(3)

Silver C

(3)

Matthew AN

(2)

Baker D

(1)

Brunette TJ

(1)

Cunningham-Bryant D

(1)

Foight GW

(1)

Jr Greisen P

(1)

Kurt Yilmaz N

(1)

Maly DJ

(1)

Park K

(1)

Prachanronarong KL

(1)

Royer WE

(1)

Sheffler W

(1)

Soumana DI

(1)

Wang Z

(1)

Warner KM

(1)

Wei CT

(1)

Yilmaz NK

(1)

Homo / hetero assembly  (2)

homo

(7)

hetero

(1)

Assembly composition  (2)

protein structure

(7)

protein/protein complex

(1)

Assembly polymer count  (2)

monomer

(7)

dimer

(1)

Resolution distribution

1.0 - 1.5

(5)

1.5 - 2

(2)

2.0 - 2.5

(1)

Release year distribution

2005 - 2010

(1)

2010 - 2015

(4)

2015 - 2020

(4)

Journal  (5)

PLoS Pathog

(3)

To be published

(2)

J Am Chem Soc

(1)

Nat Biotechnol

(1)

Proc Natl Acad Sci U S A

(1)

Organism superkingdom  (1)

Viruses

(8)

Organism name  (3)

hepatitis C virus genotype 1a

(5)

Hepacivirus hominis

(3)

synthetic construct

(1)

Molecule name  (40)

Genome polyprotein

(6)

Polyprotein

(5)

NS3 protease

(3)

Peptidase S29 domain-containing protein

(2)

Capsid protein C

(1)

Core protein precursor

(1)

Envelope glycoprotein E1

(1)

Envelope glycoprotein E2

(1)

Hepacivirin

(1)

Mature core protein

(1)

NS1

(1)

NS2

(1)

NS3 helicase

(1)

NS3/4A

(1)

NS3P

(1)

NS4A

(1)

NS4A COFACTOR-NS3 PROTEIN CHIMERA

(1)

NS4B

(1)

NS5A

(1)

NS5B

(1)

Non-structural protein 2

(1)

Non-structural protein 4A

(1)

Non-structural protein 4B

(1)

Non-structural protein 5A

(1)

Protease NS2

(1)

RNA-directed RNA polymerase

(1)

Rosetta-designed danoprevir/NS3a complex reader 2

(1)

Serine protease/helicase NS3

(1)

Viroporin p7

(1)

Viroporin p70

(1)

gp32

(1)

gp35

(1)

gp68

(1)

gp70

(1)

p21

(1)

p23

(1)

p27

(1)

p56/58

(1)

p68

(1)

p8

(1)

Molecule type  (1)

Protein

(8)

Interacting Molecules  (2)

Rosetta-designed danoprevir/NS3a complex reader 2

(1)

Serine protease/helicase NS3

(1)

Interacting ligands  (4)

TSV : (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate

(8)

ZN : ZINC ION

(8)

SO4 : SULFATE ION

(7)

GOL : GLYCEROL

(1)

EC number / name  (4)

3.6.4.13 : RNA helicase

(8)

3.4.21.98 : Hepacivirin

(6)

3.6.1.15 : Nucleoside-triphosphate phosphatase

(6)

2.7.7.48 : RNA-directed RNA polymerase

(1)

Biological function  (4)

serine-type peptidase activity

(8)

hydrolase activity

(2)

metal ion binding

(2)

peptidase activity

(2)

Biological process  (5)

proteolysis

(8)

symbiont-mediated transformation of host cell

(8)

symbiont entry into host cell

(2)

virion attachment to host cell

(2)

carbohydrate metabolic process

(1)

Biological cell component  (5)

host cell

(2)

host cell membrane

(2)

membrane

(2)

virion component

(2)

virion membrane

(2)

CATH class  (1)

Mainly Beta

(7)

CATH topology  (1)

Thrombin, subunit H

(7)

Representative Structures

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