Entry status  (1)

REL

(10)

Experimental methods  (1)

X-ray diffraction

(10)

Authors  (44)

Ayaz P

(4)

Beyett TS

(4)

Choi HG

(4)

De Clercq DJH

(4)

Eck MJ

(4)

Gomez G

(4)

Gray NS

(4)

Heppner DE

(4)

Huang X

(4)

Jang J

(4)

Janne PA

(4)

Li JL

(4)

Liang L

(4)

Rana JK

(4)

Schmoker AM

(4)

Scott DA

(4)

Shan Y

(4)

Shaw DE

(4)

To C

(4)

Wu YC

(4)

Yan XE

(4)

Yun CH

(4)

Zhang CH

(4)

Zhao P

(4)

Zhu SJ

(4)

Chiba T

(1)

Dickson JM

(1)

Endo M

(1)

Flanagan JU

(1)

Fukami TA

(1)

Kashima K

(1)

Kawauchi H

(1)

McKeage M

(1)

McKeage MJ

(1)

Patterson AV

(1)

Sakamoto H

(1)

Sato S

(1)

Silva S

(1)

Smaill JB

(1)

Squire CJ

(1)

Tachibana Y

(1)

Tanimura H

(1)

Torizawa T

(1)

Yosaatmadja Y

(1)

Homo / hetero assembly  (1)

homo

(10)

Assembly composition  (1)

protein structure

(10)

Assembly polymer count  (2)

monomer

(6)

dimer

(4)

Resolution distribution

2.0 - 2.5

(5)

2.5 - 3

(5)

Release year distribution

2010 - 2015

(1)

2015 - 2020

(6)

2020 - 2025

(9)

Journal  (4)

J Med Chem

(4)

Nat Commun

(4)

J Struct Biol

(1)

Mol Cancer Ther

(1)

Organism superkingdom  (1)

Eukaryota

(10)

Organism name  (1)

Homo sapiens

(10)

Molecule name  (3)

Epidermal growth factor receptor

(10)

Proto-oncogene c-ErbB-1

(10)

Receptor tyrosine-protein kinase erbB-1

(10)

Molecule type  (1)

Protein

(10)

Gene names  (4)

EGFR

(10)

ERBB

(10)

ERBB1

(10)

HER1

(10)

Interacting ligands  (7)

YY3 : N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide

(10)

ANP : PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

(2)

CL : CHLORIDE ION

(2)

MG : MAGNESIUM ION

(2)

VNS : (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide

(2)

9LL : (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

(1)

JBJ : (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide

(1)

EC number / name  (1)

2.7.10.1 : Receptor protein-tyrosine kinase

(10)

Biological function  (3)

ATP binding

(10)

protein kinase activity

(10)

protein tyrosine kinase activity

(10)

Biological process  (1)

protein phosphorylation

(10)

CATH class  (2)

Alpha Beta

(1)

Mainly Alpha

(1)

CATH topology  (2)

Phosphorylase Kinase; domain 1

(1)

Transferase(Phosphotransferase); domain 1

(1)

Pfam accession / name  (1)

PF07714 : PK_Tyr_Ser-Thr

(10)

Diffraction protocol  (1)

Single wavelength

(10)

Diffraction radiation source type  (2)

Synchrotron

(9)

Rotating anode

(1)

Diffraction source  (7)

APS BEAMLINE 24-ID-E

(3)

APS BEAMLINE 19-ID

(2)

APS BEAMLINE 24-ID-C

(1)

PHOTON FACTORY BEAMLINE BL-17A

(1)

RIGAKU MICROMAX-007 HF

(1)

SSRF BEAMLINE BL18U1

(1)

SSRF BEAMLINE BL19U1

(1)

Synchrotron site  (3)

APS

(6)

SSRF

(2)

Photon Factory

(1)

Diffraction detector type  (3)

Pixel

(7)

CCD

(2)

Image plate

(1)

Refinement software  (2)

PHENIX

(9)

REFMAC

(1)

Representative Structures

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