Entry status  (1)

REL

(27)

Experimental methods  (1)

X-ray diffraction

(27)

Authors  (160)

Gao GF

(8)

Qi J

(8)

Wu Y

(7)

Collins PJ

(6)

Gamblin SJ

(6)

Gao F

(6)

Skehel JJ

(6)

Vavricka CJ

(6)

Liu J

(5)

Colman PM

(4)

Haire LF

(4)

Hay AJ

(4)

He J

(4)

Li Q

(4)

Liu WJ

(4)

Vachieri SG

(4)

Xiao H

(4)

Liu Y

(3)

Martin SR

(3)

Qi JX

(3)

Stevens J

(3)

Varghese JN

(3)

Walker PA

(3)

Wang M

(3)

Bi Y

(2)

Bi YH

(2)

Boucher CA

(2)

Boucher CAB

(2)

Caro V

(2)

Casalegno J

(2)

Casalegno JS

(2)

Cattle N

(2)

Chai Y

(2)

Daniels RS

(2)

Davis CT

(2)

Epa VC

(2)

Escuret V

(2)

Feng E

(2)

Ferraris O

(2)

Frobert E

(2)

Gamblin S

(2)

Garman EF

(2)

Gubareva LV

(2)

Guo Z

(2)

He JH

(2)

Jiang H

(2)

Laver WG

(2)

Li D

(2)

Li L

(2)

Lin YP

(2)

Lina B

(2)

Liu H

(2)

Liu W

(2)

McCauley JW

(2)

McKimm-Breschkin JL

(2)

Mccauley JW

(2)

Osterhaus AD

(2)

Osterhaus ADME

(2)

Ottmann M

(2)

Peng W

(2)

Qin C

(2)

Qin CF

(2)

Russell RJ

(2)

Sabatier M

(2)

Schutten M

(2)

Smith PW

(2)

Sollis SL

(2)

Sun L

(2)

Sun X

(2)

Sun XM

(2)

Valette M

(2)

Valla F

(2)

Van Der Vries E

(2)

Wang J

(2)

Xiao HX

(2)

Xiong X

(2)

Yan J

(2)

Yan JH

(2)

Yang H

(2)

Zhang Y

(2)

Zhang YF

(2)

Zhao M

(2)

van der Vries E

(2)

von Itzstein M

(2)

Baranovich T

(1)

Bethell R

(1)

Blackburn GM

(1)

Blick TJ

(1)

Borg NA

(1)

Brooke CB

(1)

Carney PJ

(1)

Chang JC

(1)

Chavas LMG

(1)

Cherry PC

(1)

Cleasby A

(1)

Colllins P

(1)

Colman P

(1)

Crennell SJ

(1)

Diefenbacher M

(1)

Dwek RA

(1)

 

More...

Homo / hetero assembly  (1)

homo

(27)

Assembly composition  (1)

protein structure

(27)

Assembly polymer count  (3)

tetramer

(22)

monomer

(3)

dimer

(2)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(16)

2.0 - 2.5

(6)

2.5 - 3

(3)

Release year distribution

1995 - 2000

(3)

2000 - 2005

(1)

2005 - 2010

(5)

2010 - 2015

(12)

2015 - 2020

(4)

2020 - 2025

(3)

Journal  (13)

J Virol

(4)

PLoS Pathog

(4)

J Infect Dis

(3)

To be published

(3)

Cell Res

(2)

J Mol Biol

(2)

Nature

(2)

Proc Natl Acad Sci U S A

(2)

J Med Chem

(1)

Molecules

(1)

Nat Commun

(1)

Protein Sci

(1)

Structure

(1)

Organism superkingdom  (3)

Viruses

(24)

Bacteria

(2)

Eukaryota

(1)

Organism name  (21)

Influenza A virus

(6)

Influenza A virus (A/tern/Australia/G70C/1975(H11N9))

(2)

Homo sapiens

(1)

Human respirovirus 3

(1)

Influenza A virus (A/California/04/2009(H1N1))

(1)

Influenza A virus (A/California/07/2009(H1N1))

(1)

Influenza A virus (A/Netherlands/2631_1202/2010(H1N1))

(1)

Influenza A virus (A/RI/5+/1957(H2N2))

(1)

Influenza A virus (A/Shandong/9/1993(H3N2))

(1)

Influenza A virus (A/Shanghai/02/2013(H7N9))

(1)

Influenza A virus (A/Viet Nam/1203/2004(H5N1))

(1)

Influenza A virus (A/duck/Alberta/60/1976(H12N5))

(1)

Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))

(1)

Influenza A virus (A/swine/Missouri/2124514/2006(H2N3))

(1)

Influenza B virus

(1)

Influenza B virus (B/Brisbane/60/2008)

(1)

Influenza B virus (STRAIN B/BEIJING/1/87)

(1)

Streptococcus pneumoniae TIGR4

(1)

Vibrio cholerae O1 biovar El Tor str. N16961

(1)

Wuhan spiny eel influenza virus

(1)

unidentified influenza virus

(1)

Molecule name  (10)

Neuraminidase

(24)

NA

(2)

Cytosolic sialidase

(1)

Hemagglutinin-neuraminidase glycoprotein

(1)

N-acetyl-alpha-neuraminidase 2

(1)

NANase

(1)

Neuraminidase A

(1)

Sialidase

(1)

Sialidase A

(1)

Sialidase-2

(1)

Molecule type  (1)

Protein

(27)

Gene names  (6)

NA

(23)

HN

(1)

NEU2

(1)

VC_1784

(1)

nanA

(1)

nanH

(1)

Interacting ligands  (13)

ZMR : ZANAMIVIR

(27)

CA : CALCIUM ION

(24)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(21)

BMA : beta-D-mannopyranose

(12)

MAN : alpha-D-mannopyranose

(10)

GOL : GLYCEROL

(5)

FUC : alpha-L-fucopyranose

(3)

EDO : 1,2-ETHANEDIOL

(2)

ACT : ACETATE ION

(1)

CL : CHLORIDE ION

(1)

NA : SODIUM ION

(1)

PEG : DI(HYDROXYETHYL)ETHER

(1)

SO4 : SULFATE ION

(1)

EC number / name  (1)

3.2.1.18 : Exo-alpha-sialidase

(27)

Biological function  (7)

exo-alpha-sialidase activity

(27)

hydrolase activity

(8)

hydrolase activity, acting on glycosyl bonds

(8)

metal ion binding

(6)

host cell surface receptor binding

(1)

protein binding

(1)

sialic acid binding

(1)

Biological process  (9)

carbohydrate metabolic process

(23)

viral budding from plasma membrane

(15)

ganglioside catabolic process

(2)

oligosaccharide catabolic process

(2)

glycoprotein catabolic process

(1)

glycosphingolipid catabolic process

(1)

lipid catabolic process

(1)

lipid metabolic process

(1)

viral life cycle

(1)

Biological cell component  (12)

membrane

(25)

host cell membrane

(23)

virion membrane

(23)

host cell plasma membrane

(6)

virion component

(6)

cytoplasm

(2)

catalytic complex

(1)

cytosol

(1)

extracellular region

(1)

intracellular membrane-bounded organelle

(1)

lysosome

(1)

viral envelope

(1)

SCOP fold  (1)

6-bladed beta-propeller

(5)

SCOP family  (1)

Sialidases (neuraminidases)

(5)

CATH class  (1)

Mainly Beta

(24)

CATH topology  (3)

Neuraminidase

(24)

Intramolecular trans-sialidase; domain 3

(1)

Jelly Rolls

(1)

Pfam accession / name  (4)

PF00064 : Neur

(23)

PF13088 : BNR_2

(2)

PF00423 : HN

(1)

PF09264 : Sial-lect-inser

(1)

Diffraction protocol  (1)

Single wavelength

(24)

Diffraction radiation source type  (2)

Synchrotron

(23)

Rotating anode

(5)

Diffraction source  (22)

SSRF BEAMLINE BL17U

(3)

APS BEAMLINE 22-ID

(2)

DIAMOND BEAMLINE I04

(2)

PHOTON FACTORY BEAMLINE AR-NE3A

(2)

SSRL BEAMLINE BL11-1

(2)

APS BEAMLINE 14-ID-B

(1)

APS BEAMLINE 21-ID-D

(1)

BESSY BEAMLINE 14.1

(1)

DIAMOND

(1)

DIAMOND BEAMLINE I03

(1)

ESRF BEAMLINE BM14

(1)

MACSCIENCE M18X

(1)

PHOTON FACTORY BEAMLINE AR-NW12A

(1)

PHOTON FACTORY BEAMLINE BL-17A

(1)

PHOTON FACTORY BEAMLINE BL-6A

(1)

RIGAKU

(1)

RIGAKU MICROMAX-007

(1)

RIGAKU RU200

(1)

RIGAKU RU200H

(1)

SRS BEAMLINE PX9.6

(1)

SSRF BEAMLINE BL02U1

(1)

SSRF BEAMLINE BL17U1

(1)

Synchrotron site  (8)

Photon Factory

(5)

SSRF

(5)

APS

(4)

Diamond

(4)

SSRL

(2)

BESSY

(1)

ESRF

(1)

SRS

(1)

Diffraction detector type  (3)

CCD

(14)

Pixel

(7)

Image plate

(6)

Refinement software  (4)

PHENIX

(13)

REFMAC

(8)

CNS

(3)

X-PLOR

(3)

Representative Structures

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