› 2l84

Solution NMR

Solution NMR structures of CBP bromodomain with small molecule j28

Released:
DOI: 10.2210/pdb2l84/pdb
PDB entry 2l84 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l84 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l84 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Borah JC, Mujtaba S, Karakikes I, Zeng L, Muller M, Patel J, Moshkina N, Morohashi K, Zhang W, Gerona-Navarro G, Hajjar RJ, Zhou MM
Chem Biol 18 531-41 (2011)
PMID: 21513889

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-571662 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 14.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 1520
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand J28 1 x J28
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli 1520

Quick links

Citations

30 review citations

Epigenetic protein families: a new frontier for drug discovery.
Arrowsmith et al. (2012)
29 more

7 mentions without citation

Protein lysine acetylation by p300/CBP.
Dancy et al. (2015)
6 more