2zck

X-ray diffraction
3.1Å resolution

Crystal structure of a ternary complex between PSA, a substrat-acyl intermediate and an activating antibody

Released:
Model geometry
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Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-233925 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Prostate-specific antigen Chain: P
Molecule details ›
Chain: P
Length: 237 amino acids
Theoretical weight: 26.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07288 (Residues: 25-261; Coverage: 97%)
Gene names: APS, KLK3
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
KGISSQY Chain: S
Molecule details ›
Chain: S
Length: 7 amino acids
Theoretical weight: 783 Da
monoclonal antibody 8G8F5 Fab Chain: L
monoclonal antibody 8G8F5 Fab Chain: H

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P41212
Unit cell:
a: 86.765Å b: 86.765Å c: 238.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.275