3sbl

X-ray diffraction
2.31Å resolution

Crystal Structure of New Delhi Metal-beta-lactamase-1 from Klebsiella pneumoniae

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
PDBe Complex ID:
PDB-CPX-111680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallo-beta-lactamase type 2 Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 25.1 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: C7C422 (Residues: 39-270; Coverage: 96%)
Gene name: blaNDM-1
Sequence domains: Metallo-beta-lactamase superfamily
Structure domains: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I222
Unit cell:
a: 66.05Å b: 83.269Å c: 105.401Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.26
Expression system: Escherichia coli

PDB-REDO

Experimental raw data