› 3me4

X-ray diffraction
2.01Å resolution

Crystal structure of mouse RANK

Released:
DOI: 10.2210/pdb3me4/pdb
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PDB entry 3me4 coloured by chain, front view.
PDB entry 3me4 coloured by chain, side view.
PDB entry 3me4 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional insights of RANKL-RANK interaction and signaling.
Liu C, Walter TS, Huang P, Zhang S, Zhu X, Wu Y, Wedderburn LR, Tang P, Owens RJ, Stuart DI, Ren J, Gao B
J Immunol 184 6910-9 (2010)
PMID: 20483727

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 11A Chains: A, B
Molecule details ›
Chains: A, B
Length: 216 amino acids
Theoretical weight: 24.02 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35305 (Residues: 26-210; Coverage: 30%)
Gene names: Rank, Tnfrsf11a
Sequence domains:
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

5 bound ligands:
Ligand NA 2 x NA
Ligand CL 3 x CL
Ligand SO4 2 x SO4
Ligand GOL 4 x GOL
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 39.819Å b: 94.245Å c: 102.418Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.233
Expression system: Escherichia coli

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Citations

16 review citations

Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.
Lacey et al. (2012)
15 more

2 mentions without citation

RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations.
Pangrazio et al. (2012)
1 more

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