3qhr

X-ray diffraction
2.17Å resolution

Structure of a pCDK2/CyclinA transition-state mimic

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-150317 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Cyclin-A2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 261 amino acids
Theoretical weight: 29.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
CDK2 substrate peptide: PKTPKKAKKL Chains: J, K, L, M

Ligands and Environments

1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 70.69Å b: 163.91Å c: 73.28Å
α: 90° β: 107.38° γ: 90°
R-values:
R R work R free
0.18 0.179 0.21
Expression systems:
  • Escherichia coli
  • Not provided