› 3rq3

X-ray diffraction
2.7Å resolution

Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form

Released:
DOI: 10.2210/pdb3rq3/pdb
PDB entry 3rq3 coloured by chain, front view.
PDB entry 3rq3 coloured by chain, side view.
PDB entry 3rq3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ramagopal UA, Rubinstein R, Guo H, Samanta D, Nathenson SG, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175401 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell immunoreceptor with Ig and ITIM domains Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q495A1 (Residues: 22-137; Coverage: 52%)
Gene names: TIGIT, VSIG9, VSTM3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P6422
Unit cell:
a: 118.614Å b: 118.614Å c: 98.197Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.253
Expression system: Escherichia coli

Quick links