› 3ws6

X-ray diffraction
1.98Å resolution

Crystal Structure of H-2D in complex with a mimotopic peptide

Released:
DOI: 10.2210/pdb3ws6/pdb
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PDB entry 3ws6 coloured by chain, front view.
PDB entry 3ws6 coloured by chain, side view.
PDB entry 3ws6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses.
Lamont D, Mukherjee G, Kumar PR, Samanta D, McPhee CG, Kay TW, Almo SC, DiLorenzo TP, Serreze DV
J Immunol 193 2135-46 (2014)
PMID: 25063871

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135005 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, D-B alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 32.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01899 (Residues: 26-300; Coverage: 81%)
Gene name: H2-D1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: C, D
Molecule details ›
Chains: C, D
Length: 100 amino acids
Theoretical weight: 11.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Mimotope 9-mer peptide Chains: E, F

Ligands and Environments

4 bound ligands:
Ligand ZN 4 x ZN
Ligand IMD 6 x IMD
Ligand GOL 4 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 162.723Å b: 69.265Å c: 73.753Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.169 0.224
Expression system: Escherichia coli

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Citations

6 review citations

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.
Pearson et al. (2016)
5 more

1 mention without citation

Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses.
Lamont et al. (2014)

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