4r6u

X-ray diffraction
2.8Å resolution

IL-18 receptor complex

Released:
Model geometry
Fit model/data
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-171711 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-18 receptor 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 317 amino acids
Theoretical weight: 36.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13478 (Residues: 19-329; Coverage: 60%)
Gene names: IL18R1, IL1RRP
Structure domains: Immunoglobulins
Interleukin-18 Chains: B, D
Molecule details ›
Chains: B, D
Length: 157 amino acids
Theoretical weight: 18.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14116 (Residues: 37-193; Coverage: 81%)
Gene names: IGIF, IL18, IL1F4
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 71.392Å b: 85.603Å c: 88.117Å
α: 90° β: 97.6° γ: 90°
R-values:
R R work R free
0.236 0.233 0.282
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli