› 5l9e

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER

Released:
DOI: 10.2210/pdb5l9e/pdb
PDB entry 5l9e coloured by chain, front view.
PDB entry 5l9e coloured by chain, side view.
PDB entry 5l9e coloured by chain, top view.
Source organisms:
Entry authors: Vallade M, Langlois d'Estaintot B, Granier T, Huc I

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250963 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Carbonic anhydrase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase
Aromatic foldamer Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 6 amino acids
Theoretical weight: 1.39 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ZN 27 x ZN
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Unit cell:
a: 125.972Å b: 75.14Å c: 141.098Å
α: 90° β: 100.08° γ: 90°
R-values:
R R work R free
0.244 0.242 0.273
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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