6agf

Electron Microscopy
3.2Å resolution

Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1

Released:
Source organism: Homo sapiens
Related structures: EMD-9617

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152932 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium channel protein type 4 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1879 amino acids
Theoretical weight: 212.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35499 (Residues: 1-1836; Coverage: 100%)
Gene name: SCN4A
Sequence domains:
Sodium channel regulatory subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-9617
Expression system: Homo sapiens