6mux

Electron Microscopy
3.9Å resolution

The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 35-mer (preferred)
PDBe Complex ID:
PDB-CPX-111607 (preferred)
Entry contents:
15 distinct polypeptide molecules
Macromolecules (15 distinct):
Proteasome alpha-type subunits domain-containing protein Chains: A, O
Molecule details ›
Chains: A, O
Length: 260 amino acids
Theoretical weight: 29.53 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IAR3 (Residues: 1-260; Coverage: 100%)
Gene name: PF3D7_0807500
Sequence domains:
Proteasome alpha-type subunits domain-containing protein Chains: B, P
Molecule details ›
Chains: B, P
Length: 235 amino acids
Theoretical weight: 26.56 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: C6KST3 (Residues: 1-235; Coverage: 100%)
Gene name: PF3D7_0608500
Sequence domains:
Proteasome subunit alpha type Chains: C, Q
Proteasome subunit alpha type Chains: D, R
Proteasome subunit alpha type Chains: E, S
Proteasome alpha-type subunits domain-containing protein Chains: F, T
Proteasome alpha-type subunits domain-containing protein Chains: G, U
Proteasome subunit beta type-6, putative Chains: H, V
Proteasome subunit beta Chains: I, W
Proteasome subunit beta Chains: J, X
Proteasome subunit beta Chains: K, Y
Proteasome subunit beta Chains: L, Z
20S proteasome beta-6 subunit Chains: M, a
Proteasome subunit beta Chains: N, b
Proteasome activator PA28 C-terminal domain-containing protein Chains: c, d, e, f, g, h, i

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-9259
Expression system: Escherichia coli BL21(DE3)