› 6sqm

X-ray diffraction
1.8Å resolution

Crystal structure of CREBBP bromodomain complexed with LA36

Released:
DOI: 10.2210/pdb6sqm/pdb
PDB entry 6sqm coloured by chain, front view.
PDB entry 6sqm coloured by chain, side view.
PDB entry 6sqm coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bedi RK, Laul E, Nevado C, Caflisch A

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand LU5 3 x LU5
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 126.8Å b: 37.6Å c: 90.46Å
α: 90° β: 116.2° γ: 90°
R-values:
R R work R free
0.211 0.208 0.269
Expression system: Escherichia coli BL21(DE3)

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