7l1u

Electron Microscopy
3.2Å resolution

Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-208087 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Engineered Guanine nucleotide-binding protein subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 28.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 349 amino acids
Theoretical weight: 38.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
single-chain antibody Fv fragment (svFv16) Chain: H
Orexin receptor type 2 Chain: R
Orexin-B Chain: L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-23118
Expression systems:
  • Escherichia coli
  • Trichoplusia ni
  • Homo sapiens
  • Not provided