7m3e

Electron Microscopy
3.2Å resolution

Asymmetric Activation of the Calcium Sensing Receptor Homodimer

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-154256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Extracellular calcium-sensing receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 902 amino acids
Theoretical weight: 101.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41180 (Residues: 20-894; Coverage: 83%)
Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-23652
Expression system: Spodoptera frugiperda