8f2q

X-ray diffraction
2.7Å resolution

Human Parvovirus B19 Nonstructural NS1 Protein NLS bound to Importin Alpha 2

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-273860 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 510 amino acids
Theoretical weight: 55.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-529; Coverage: 87%)
Gene names: Kpna2, Rch1
Sequence domains:
Initiator protein NS1 Chains: B, C
Molecule details ›
Chains: B, C
Length: 11 amino acids
Theoretical weight: 1.19 KDa
Source organism: Human parvovirus B19
Expression system: Not provided
UniProt:
  • Canonical: Q9PZT1 (Residues: 172-182; Coverage: 2%)
Gene name: NS1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 78.197Å b: 90.188Å c: 100.512Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.229
Expression systems:
  • Escherichia coli
  • Not provided