8qeo

Electron Microscopy
3.26Å resolution

cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-271825 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Toxin B Chain: A
Molecule details ›
Chain: A
Length: 2397 amino acids
Theoretical weight: 273.55 KDa
Source organism: Clostridioides difficile
Expression system: Priestia megaterium DSM 319
UniProt:
  • Canonical: P18177 (Residues: 1-2366; Coverage: 100%)
Gene names: tcdB, toxB
Sequence domains:
Frizzled-7 Chain: B
Molecule details ›
Chain: B
Length: 603 amino acids
Theoretical weight: 67.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75084 (Residues: 33-574; Coverage: 100%)
Gene name: FZD7
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-18374
Expression systems:
  • Priestia megaterium DSM 319
  • Spodoptera frugiperda