8sk2

X-ray diffraction
1.3Å resolution

X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia, apo form

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-111680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallo-beta-lactamase type 2 Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 28.38 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C7C422 (Residues: 2-270; Coverage: 100%)
Gene name: blaNDM-1
Sequence domains: Metallo-beta-lactamase superfamily

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER D8 QUEST
Spacegroup: P21
Unit cell:
a: 39.927Å b: 59.312Å c: 41.815Å
α: 90° β: 98.65° γ: 90°
R-values:
R R work R free
0.179 0.178 0.199
Expression system: Escherichia coli BL21(DE3)