8y93

Electron Microscopy
3Å resolution

Structure of NET-Amitriptyline in outward-open state

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-273415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent noradrenaline transporter Chains: A, E
Molecule details ›
Chains: A, E
Length: 617 amino acids
Theoretical weight: 69.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23975 (Residues: 1-617; Coverage: 100%)
Gene names: NAT1, NET1, SLC6A2, SLC6A5
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-39068
Expression system: Homo sapiens