› 1bi3

X-ray diffraction
2.4Å resolution

STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR

Released:
DOI: 10.2210/pdb1bi3/pdb
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PDB entry 1bi3 coloured by chain, front view.
PDB entry 1bi3 coloured by chain, side view.
PDB entry 1bi3 coloured by chain, top view.
Source organism: Corynebacterium diphtheriae
Primary publication:
Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
Pohl E, Holmes RK, Hol WG
J Biol Chem 273 22420-7 (1998)
PMID: 9712865

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143594 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diphtheria toxin repressor Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 25.38 KDa
Source organism: Corynebacterium diphtheriae
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DJL7 (Residues: 1-226; Coverage: 100%)
Gene names: DIP1414, dtxR
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand SO4 2 x SO4
1 modified residue:
Ligand CSS 2 x CSS

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS
Spacegroup: P3221
Unit cell:
a: 63.4Å b: 63.4Å c: 213.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.253 0.253 0.333
Expression system: Escherichia coli

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Citations

5 review citations

Bacterial iron homeostasis.
Andrews et al. (2003)
4 more

2 mentions without citation

ProBiS-CHARMMing: Web Interface for Prediction and Optimization of Ligands in Protein Binding Sites.
Konc et al. (2015)
1 more

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